Heterogeneity Among Liver Cancer—A Hurdle to Optimizing Therapy

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Heterogeneity Among Liver Cancer—A Hurdle to Optimizing Therapy Nicolai Juul Birkbak Gastroenterology Volume 150, Issue 4, Pages 818-821 (April 2016) DOI: 10.1053/j.gastro.2016.02.063 Copyright © 2016 AGA Institute Terms and Conditions

Figure 1 Spectrum of intratumor heterogeneity (ITH). Model depicting the evolution and spread of liver cancer from the onset to local metastasis. The primary tumor consists of four different subclones with distinct molecular compositions. These clones represent the intratumor heterogeneity (ITH) of the tumor. Green highlights primary tumor (P). IM, intrahepatic metastasis (red); TT, tumor thrombus (blue); SN, satellite nodule (yellow). Gastroenterology 2016 150, 818-821DOI: (10.1053/j.gastro.2016.02.063) Copyright © 2016 AGA Institute Terms and Conditions