Figure 2 MRIs (cases 2 and 3)‏

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Figure 2 MRIs (cases 2 and 3)‏ MRIs (cases 2 and 3) In both the second and third cases, MRI performed because of clinical deterioration revealed highly progressive multifocal leukoencephalopathy-suspicious T2 lesions involving subcortical U-fibers (A, D), without a contrast enhancement in T1 (B). Follow-up MRI 4 weeks later revealed massive progression in a second patient (C, no contrast enhancement imaging performed) and only moderate enlargement in the left hemisphere in a third one (E) with discretfully scattered punctate contrast enhancement in the margins of the right-sided lesion (red arrow) consistent with a milder immune reconstitution inflammatory syndrome (F). Jin Nakahara et al. Neurol Neuroimmunol Neuroinflamm 2019;6:e559 Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.