Activation of the MAPK/Erk cascade is involved in the formation of functional synapses between B2 neurons. Activation of the MAPK/Erk cascade is involved.

Slides:

Advertisements

Similar presentations

Neural Signaling: Postsynaptic Potentials Lesson 9.

Advertisements

Neuromuscular Transmission synaptic transmission between a somatic motor neuron and a skeletal muscle fiber Somatic Fig

Synaptic Nerve Transmission Getting the Message From Here to There.

Inhibitory and Excitatory Signals

Structure and Control of Movement

Neural communication How do neurons send messages to each other?

The Integrate and Fire Model Gerstner & Kistler – Figure 4.1 RC circuit Threshold Spike.

Neurons transmit the message, synapses modulate the message

Synaptic Transmission and Neural Integration

University of Jordan1 Physiology of Synapses in the CNS- L2-L4 Faisal I. Mohammed, MD, PhD.

John Donovan 4/9/12. Nervous System The nervous system function is to send electronic signals to different parts of the body to signal them to do a task,

Synaptic Transmission and Neural Integration

Dopamine (DA) neuron Cell body (Soma) terminals axons Dendrites.

Announcements –Midterm room assignments Thursday –Midterm conflict policy posted later tonight –Some practice questions from previous midterms will be.

LECTURE 8: SYNAPTIC TRANSMISSION OVERVIEW AND NMJ REQUIRED READING: Kandel text, Chapters 10,11 In humans, neurons, each receiving average of

Chapter 34 Opener Chapter 34: Neurons and The Nervous System.

The Patch Clamp Method 1976 by Erwin Neher and Bert Sakmann at the Max Planck Institute in Goettingen.

NERVE CELLS by Grace Minter.

9/27/16 – W4D2H4 Synaptic Transmission

Animal Cell Chromatin.

What is the part of the neuron that receives signals? Sends them?

Neuron Function.

Animal Cell Chromatin.

Christian Rosenmund, Charles F Stevens Neuron

Electrical Signals 2 BIOL 1407.

Margaret Lin Veruki, Espen Hartveit Neuron

Neurotransmitter Receptors

Polarity of Long-Term Synaptic Gain Change Is Related to Postsynaptic Spike Firing at a Cerebellar Inhibitory Synapse Carlos D Aizenman, Paul B Manis,

Yan-You Huang, Eric R Kandel Neuron

Neuron Physiology.

A Role of Intracellular Na+ in the Regulation of Synaptic Transmission and Turnover of the Vesicular Pool in Cultured Hippocampal Cells Alexandre Bouron,

NMDA Induces Long-Term Synaptic Depression and Dephosphorylation of the GluR1 Subunit of AMPA Receptors in Hippocampus Hey-Kyoung Lee, Kimihiko Kameyama,

Effects of Excitatory and Inhibitory Potentials on Action Potentials

Volume 18, Issue 6, Pages (June 1997)

PSA–NCAM Is Required for Activity-Induced Synaptic Plasticity

Heterosynaptic LTD of Hippocampal GABAergic Synapses

Yali Zhao, Ashok N Hegde, Kelsey C Martin Current Biology

Neural Signaling: Postsynaptic Potentials

Volume 18, Issue 3, Pages (March 1997)

Efficacy of Thalamocortical and Intracortical Synaptic Connections

Zhiru Wang, Ning-long Xu, Chien-ping Wu, Shumin Duan, Mu-ming Poo

A Cooperative Switch Determines the Sign of Synaptic Plasticity in Distal Dendrites of Neocortical Pyramidal Neurons Per Jesper Sjöström, Michael Häusser

Disparate Postsynaptic Induction Mechanisms Ultimately Converge to Drive the Retrograde Enhancement of Presynaptic Efficacy Pragya Goel, Xiling Li, Dion.

Dario Brambilla, David Chapman, Robert Greene Neuron

Synapse-Specific Adaptations to Inactivity in Hippocampal Circuits Achieve Homeostatic Gain Control while Dampening Network Reverberation Jimok Kim,

Volume 22, Issue 4, Pages (April 1999)

Kainate Receptors in Health and Disease

Serotonergic Modulation of Sensory Representation in a Central Multisensory Circuit Is Pathway Specific Zheng-Quan Tang, Laurence O. Trussell Cell Reports

6.5 – Neurones and Synapses

Animal Cell Cell Membrane.

Dendritically Released Peptides Act as Retrograde Modulators of Afferent Excitation in the Supraoptic Nucleus In Vitro Samuel B Kombian, Didier Mouginot,

Intracellular injection of apSyn enhances evoked neurotransmitter release from C1 neuron somata cultured under low-release conditions. Intracellular injection.

Voltage-gated ion channels Transmembrane ion channels regulated by changes in membrane potential

Christian Rosenmund, Charles F Stevens Neuron

Parallel Molecular Pathways Mediate Expression of Distinct Forms of Intermediate-Term Facilitation at Tail Sensory–Motor Synapses in Aplysia Michael.

Unaltered presynaptic transmitter secretion during pharmacological treatments. Unaltered presynaptic transmitter secretion during pharmacological treatments.

Selective modulation of AMPAR-mediated transmission in 4E-BP2−/− mice.

CK2 phosphorylates mammalian FMRP S499.

Helix B2-B2 neuron pairs form unidirectional and bidirectional chemical synapses and exhibit short-term plasticity in vitro. Helix B2-B2 neuron pairs form.

Bath application of MEK inhibitor U0126 impairs PTP expression in B2-B2 soma pairs. Bath application of MEK inhibitor U0126 impairs PTP expression in B2-B2.

Aβ-mediated Ras-MAPK signaling and Cyclin D1 expression in B103 cells are dependent on APP expression and can be reversed with MEK or Ras inhibition. Aβ-mediated.

Rapid Neocortical Dynamics: Cellular and Network Mechanisms

Alexandre Mathy, Beverley A. Clark, Michael Häusser Neuron

Expression of RGS2 Alters the Coupling of Metabotropic Glutamate Receptor 1a to M- Type K+ and N-Type Ca2+ Channels Paul J. Kammermeier, Stephen R. Ikeda

BACHD mice demonstrate decreases in synaptic activity of medium-sized spiny neurons at 6 months. BACHD mice demonstrate decreases in synaptic activity.

Christian Hansel, David J. Linden Neuron

Desdemona Fricker, Richard Miles Neuron

Exposure of in vitro sensorimotor synaptic connections to RNA from trained animals enhanced the strength of a subpopulation of synapses. Exposure of in.

MAPK/ERK signaling regulates TLR4 gene expression in response to BRAFV600E. MAPK/ERK signaling regulates TLR4 gene expression in response to BRAFV600E.

Presentation transcript:

Activation of the MAPK/Erk cascade is involved in the formation of functional synapses between B2 neurons. Activation of the MAPK/Erk cascade is involved in the formation of functional synapses between B2 neurons. (A) Sample electrophysiological recordings illustrating the various types of synaptic transmission established by paired B2-B2 neurons. The presence and type of synaptic connections were evaluated by analyzing changes in the membrane potential of each cell during injection of either hyperpolarizing or depolarizing current (1 nA for 2 seconds) into the paired cell. (B) Time course of the occurrence of synapses with a chemical component (chemical + mixed) or electrical coupling between Helix B2-B2 neurons paired in the presence of the MEK inhibitor U0126 or vehicle (DMSO). (C) EPSP amplitudes recorded in chemically interconnected B2-B2 pairs at 24, 48 and 72 hours after pairing in the absence (DMSO) or presence of U0126 (0-48 hour U0126) reveal that chronic inhibition of MAPK/Erk virtually blocks the progressive increase in EPSP amplitude that accompanies synapse formation. Missing time-point is due to low signal-to-noise ratio. To estimate the recovery of functional transmission, B2-B2 pairs were tested after the washout of the inhibitor (0-24 hours U0126+washout). (D) Similar EPSP rise time values are measured in both DMSO- and U0126-treated B2-B2 pairs, indicating that pharmacological treatment did not affect the neurotransmitter release machinery. Values represent means ± s.e.m. **P<0.01; *P<0.05. Carlo Natale Giuseppe Giachello et al. J Cell Sci 2010;123:881-893 © 2010.