Dectin-1 regulates innate IL-13.

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Dectin-1 regulates innate IL-13. Dectin-1 regulates innate IL-13. Clec7a+/+ and Clec7a−/− mice were sensitized and challenged with PBS or HDM. Seventy-two hours after the last challenge, lungs were harvested for determination of (A) levels of Il17A mRNA, (B) Il4 mRNA, (C) Il5 mRNA, (D) Il13 mRNA, (E) IL-13+CD4+ cells, and (F) FoxP3+CD4+ Tregs. (G) Numbers of IL-13+ ILCs in mice 24 hours after single PBS or HDM (100 μg) intratracheal inhalation. Rag1−/− or Rag1−/−Clec7a−/− mice were exposed to HDM as in Materials and Methods, and (H) AHR and (I) IL-13+ ILCs were determined. Data are means + SEM and are pooled from two independent experiments with n = 10 to 15 mice per group (A to E), representative of two experiments with n = 4 to 5 mice per group, or n = 6 to 13 animals per group (G to I). †P < 0.0001, as compared with PBS. *P < 0.05, **P < 0.01, as determined by one-way ANOVA followed by post hoc (Newman-Keuls) analysis. Naina Gour et al. Sci. Immunol. 2018;3:eaam9841 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works