Polymorphisms in folate-metabolizing genes and risk of idiopathic male infertility: a study on a Russian population and a meta-analysis  Alexandra S.

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Polymorphisms in folate-metabolizing genes and risk of idiopathic male infertility: a study on a Russian population and a meta-analysis  Alexandra S. Weiner, Uljana A. Boyarskikh, Ph.D., Elena N. Voronina, Ph.D., Alexey E. Tupikin, Olga V. Korolkova, Igor V. Morozov, Ph.D., Maxim L. Filipenko, Ph.D.  Fertility and Sterility  Volume 101, Issue 1, Pages 87-94.e3 (January 2014) DOI: 10.1016/j.fertnstert.2013.09.014 Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Folate-mediated one-carbon metabolism. AHCY, adenosylhomocysteinase; BHMT, betaine-homocysteine S-methyltransferase; CBS, cystathionine-beta-synthase; CTH, cystathionine gamma-lyase; Cys, cysteine; DHF, dihydrofolate; DHFR, dihydrofolate reductase; DMG, dimethylglycine; DMGDH, dimethylglycine dehydrogenase; GCS, glycine cleavage system; Gly, glycine; Hcy, homocysteine; MAT, S-adenosylmethionine synthetase; Met, methionine; MTHFD, 5,10-methylenetetrahydrofolate dehydrogenase; MTHFD (CH), 5,10-methenyltetrahydrofolate cyclohydrolase; MTHFD (FS), 10-formyltetrahydrofolate synthetase; MTHFR, 5,10-methylenetetrahydrofolate reductase; MTR, methionine synthase; MTRR, methionine synthase reductase; SAH, S-adenosylhomocysteine; SAM, S-adenosylmethionine; SARDH, sarcosine dehydrogenase; SHMT, serine hydroxymethyltransferase; THF, tetrahydrofolate; TYMS, thymidylate synthetase. Fertility and Sterility 2014 101, 87-94.e3DOI: (10.1016/j.fertnstert.2013.09.014) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Figure 2 (A) Flow chart of the selection of publications included in the meta-analysis. (B) Graphical representation of the meta-analysis results for MTHFR C677T. Fertility and Sterility 2014 101, 87-94.e3DOI: (10.1016/j.fertnstert.2013.09.014) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

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