Sildenafil protects the intestinal epithelium from DSS-induced damage.

Slides:

Advertisements

Similar presentations

IL-1β stimulates CXCL5 and CXCL8 gene expression and protein secretion in A549 cells in a time- and dose-dependent manner. IL-1β stimulates CXCL5 and CXCL8.

Advertisements

Resveratrol modulates DSS-induced neutrophils during colitis.

Chronic stress accelerated DSS-induced colitis.

Volume 135, Issue 2, Pages e3 (August 2008)

Histological features of murine DSS-induced colitis.

IHC analyses of levels and/or phosphorylation status of selected proteins from representative sections of ventral prostate of Hi-Myc mice. IHC analyses.

Volume 40, Issue 1, Pages (January 2014)

25(OH)D and 1,25(OH)2D perfusion treatment effect on cancer-related markers: IF stains illustrating expression levels for Ki-67 (A), cyclin D1 (B), ErbB-2.

Volume 25, Issue 4, Pages (April 2014)

Volume 15, Issue 2, Pages (February 2009)

Metformin decreases mTORC1 activity in the basal layer of oral epithelial dysplasias and mitotic activity in the hyperplastic epithelium. Metformin decreases.

Effects of SC144 on in vivo ovarian tumor.

C1ORF106 contributes to intestinal epithelial barrier function.

Gr-1+ MDSC in tumor-bearing mice produce IL-6.

Volume 139, Issue 6, Pages (December 2010)

Volume 21, Issue 6, Pages e4 (June 2017)

Effects of IL-1α on the composition of infiltrating proinflammatory cells in inflamed colons during DSS-induced colitis. Effects of IL-1α on the composition.

Histological changes in mouse colons after DSS treatment.

Imipramine and promethazine induce the apoptotic cell death of SCLC cells through activation of caspase-3. Imipramine and promethazine induce the apoptotic.

Increased resistance of GPR55-deficient mice to indomethacin-induced intestinal permeability. Increased resistance of GPR55-deficient mice to indomethacin-induced.

Volume 40, Issue 1, Pages (January 2014)

Expression changes of specific epigenetic-controlled tumor-related genes by the prenatal/maternal BSp treatment. qRT-PCR and Western blot analysis were.

Sildenafil suppresses polyp formation in the AOM/DSS model of colon cancer. Sildenafil suppresses polyp formation in the AOM/DSS model of colon cancer.

Fig. 3. Enhanced EGFR signaling in Rhbdf2P159L/P159L mice.

Expression of cGMP signaling components in polyps.

SW fraction induces S phase arrest and apoptosis.

Alterations in the Rap1 and PI3K–Akt signaling in afadin cKO mice.

IKKβ protects adipocytes from HFD-induced cell death.

CT-26 colon cancer induces the recruitment of protumor mast cells and the accumulation of MDSCs. CT-26 colon carcinoma cells (2 × 105) were injected s.c.

Effects of AG on the colon histology score in the acute DSS colitis model. Effects of AG on the colon histology score in the acute DSS colitis model. Ten.

The SFKs confer BRAF inhibitor resistance in BRAF-mutant melanoma cells. The SFKs confer BRAF inhibitor resistance in BRAF-mutant melanoma cells. A, phospho-protein.

BME treatment increases granzyme B expression in NK 3.3 cells.

Mitotic catastrophe symptoms caused by curcumin are followed by apoptosis. Mitotic catastrophe symptoms caused by curcumin are followed by apoptosis. A.

Quercetin induces arrest in G1 phase of cell cycle in P39 xenografts.

Quercetin induces apoptosis in P39 xenografts.

The effects of IAA and glycyrrhizin (Gc) on proliferation and cell-cycle distribution. The effects of IAA and glycyrrhizin (Gc) on proliferation and cell-cycle.

Effects of visfatin on the cell proliferation and phosphorylation of ERK, Akt, and GSK-3β proteins in HCC cells. Effects of visfatin on the cell proliferation.

Anti-Flk-1 mAb treatment reduces vessel density in tumors.

Immunohistochemistry for phosphorylated (S235) S6 ribosomal protein and quantitation of Ki67 labeling indices in vehicle- and WAY –treated Eker (Tsc2+/−)

Anti-Flk-1 mAb inhibits vascularization of Matrigel plugs.

A, change in Ki-67 expression (percent of cells staining positive) over the course of the intervention. A, change in Ki-67 expression (percent of cells.

N-3 PUFAs promote endometrial cancer cell apoptosis in vitro and in vivo. n-3 PUFAs promote endometrial cancer cell apoptosis in vitro and in vivo. HEC-1-A.

COX-2, Oct-4, and ALDH-1 expression in the mammary gland.

SY-1425 induces maturation in RARA-high AML

WP1066 inhibits the progression of OCIM2 cells through the cell cycle.

Mean cell number in small intestinal crypt (a), small intestinal villus (b), and midcolonic crypt (c) of BALB/c (♦) and DBA/2 (▪) mice after two injections.

Apoptotic cell index percentage (a and b) and mitotic cell index percentage (c and d) in small intestinal (a and c) and midcolonic (b and d) crypts of.

Effect of CDV on human SF7796 xenografts in vivo.

Whole-mount analysis of tumor induced lymphatic sprouting by confocal microscopy. Whole-mount analysis of tumor induced lymphatic sprouting by confocal.

Expression of PCNA, K10, and K5 in skin lesions from Stat3+/−:HPV8 and Stat3+/+:HPV8 mice. Expression of PCNA, K10, and K5 in skin lesions from Stat3+/−:HPV8.

Effects of UVB on AKT in SKH-1 mouse epidermis.

Tumor protection induced by therapeutic PLG vaccination in combination with blockade antibodies. Tumor protection induced by therapeutic PLG vaccination.

Acute phenotypes of HPV16 E6/E7 transgenic mouse anal epithelium.

Increased expression of angiogenic factors and inflammatory cytokines in mice exposed to hypoxia. Increased expression of angiogenic factors and inflammatory.

In vivo effects of TTFields on intradermal tumors in mice.

P53-expressing tumor cells circumvent mitosis, express markers consistent with a G1-like state, and become senescent in response to continuous chemotherapeutic.

Effect of MZ treatment on lung colony formation in an experimental metastasis. Effect of MZ treatment on lung colony formation in an experimental metastasis.

Ki-67 and ERα immunostaining in the mammary gland.

W. chinensis extract induces apoptosis in AR-dependent prostate cancer cells. W. chinensis extract induces apoptosis in AR-dependent prostate cancer cells.

Increased growth factor receptor expression in lungs and tumors of hypoxic mice. Increased growth factor receptor expression in lungs and tumors of hypoxic.

Effects of ZOL treatment on pulmonary metastases.

Effect of dexamethasone on PCDGF/GP88 mRNA and protein expressions and effect of PCDGF/GP88 on dexamethasone-induced cell death. Effect of dexamethasone.

Blockade of cell cycle at G2-M phase in Bel-7402 cells treated with IG-105. Blockade of cell cycle at G2-M phase in Bel-7402 cells treated with IG-105.

Mechanism by which flavopiridol induces cell cycle arrest and apoptosis in rhabdoid tumor cells. Mechanism by which flavopiridol induces cell cycle arrest.

Recruitment of CD8+, CD4+, and Foxp3+ cells into oral lesions in response to anti–PD-1 treatment. Recruitment of CD8+, CD4+, and Foxp3+ cells into oral.

Effects of inhibitors of PI3K, MEK1, and GSK-3β on visfatin-induced proliferation in HepG2 cells. Effects of inhibitors of PI3K, MEK1, and GSK-3β on visfatin-induced.

Tobacco-specific carcinogens induce methylation, DNA adducts, DNA damage, and activation of DNMT1. Tobacco-specific carcinogens induce methylation, DNA.

Dose-dependent effect of IP6 feeding on angiogenesis in prostate of TRAMP mice. Dose-dependent effect of IP6 feeding on angiogenesis in prostate of TRAMP.

PEGPH20 depletes HA and decompresses intratumoral vessels.

Determination of Per2 (left), MTNR1A (middle), and ERβ (right) protein expression levels in mammary tissues of rats sacrificed at ZT12. Determination of.

Presentation transcript:

Sildenafil protects the intestinal epithelium from DSS-induced damage. Sildenafil protects the intestinal epithelium from DSS-induced damage. A, Immunoblot shows phosphorylation of the PKG substrate vasodilator stimulated phosphoprotein (VASP-P) in colon mucosa from control and sildenafil treated groups. β-Actin is a loading control. Right, quantitation of densitometric data from blots shown on the left. B, Mucus staining (AB/PAS) of colon sections from untreated (Ctrl) and sildenafil treated mice (Sild) for 7 days. Histogram showing percentage of total AB/PAS-positive staining area. C, Ki67 staining for proliferation in colons from Ctrl and 7-day Sild-treated mice. Histogram shows percent Ki67-positive staining cells per crypt. D, Barrier permeability assessed with FITC-dextran in mice treated with 3% DSS for 5 days with or without sildenafil treatment. E, DAI in mice treated with 3% DSS for 5 days with or without sildenafil treatment. A–E,n = 3 mice per group. Scale bars in B and C, 50 μm. Bianca N. Islam et al. Cancer Prev Res 2017;10:377-388 ©2017 by American Association for Cancer Research