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© The Author(s) 2015. Published by Science and Education Publishing. Table 4. The effect of different treatments on the apoptotic index in the studied groups Group Apoptotic index (%) Normal control 7.4±0.2 UC patients before treatment 1.2±0.04a (p=0.02) UC patients treated with metformin 4.7 ± 0.18 b (p=0.023) UC patients treated with I3C 4.2 ± 0.21b (p=0.027) UC patients treated with metformin/I3C combination 5.8 ± 0.25bcd (p1=0.015; p2=0.04; p3=0.038) Apoptotic index (%) was calculated for sections of the colon (values presented as the mean ± SEM of an average of 10 fields). a Significant compared to the control group (p<0.05) b Significant compared to UC patients before treatment (p<0.05) c Significant compared to UC patients treated with metformin (p<0.05) d Significant compared to UC patients treated with I3C (p<0.05) P1 refers to metformin/I3C combination group compared to UC patients before treatment. P2 refers to metformin/I3C combination group compared to UC patients treated with metformin. P3 refers to metformin/I3C combination group compared to UC patients treated with I3C. Ahmed M. Kabel et al. Effect of Indole-3-carbinol and/or Metformin on Female Patients with Ulcerative Colitis (Premalignant Condition): Role of Oxidative Stress, Apoptosis and Proinflammatory Cytokines. Journal of Cancer Research and Treatment, 2017, Vol. 5, No. 1, 1-8. doi:10.12691/jcrt-5-1-1 © The Author(s) 2015. Published by Science and Education Publishing.