GIFT15 Bregs induce IL-10 expression in activated CD4+ T cells and enhance ex vivo formation of CD25+FoxP3+ Tregs from the spleen and CD49b+CD223+ Tr1s.

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Presentation transcript:

GIFT15 Bregs induce IL-10 expression in activated CD4+ T cells and enhance ex vivo formation of CD25+FoxP3+ Tregs from the spleen and CD49b+CD223+ Tr1s from the MLNs of mice with EAE. A, αCD3/28 Dynabead-stimulated Vert-X CD4+ T cells cultured with splenic ... GIFT15 Bregs induce IL-10 expression in activated CD4+ T cells and enhance ex vivo formation of CD25+FoxP3+ Tregs from the spleen and CD49b+CD223+ Tr1s from the MLNs of mice with EAE. A, αCD3/28 Dynabead-stimulated Vert-X CD4+ T cells cultured with splenic B cells or GIFT15 Bregs. B, CD4+ T-cell analysis from the spleens of Vert-X mice with EAE, with a clinical score of 1 or 2, cultured with splenic B cells or GIFT15 Bregs following MOG35–55 peptide stimulation. C, CD4+ T-cell analysis from the MLNs of Vert-X mice with EAE, with a clinical score of 1 or 2, cultured with splenic B cells or GIFT15 Breg following MOG35–55 peptide stimulation. Flow cytometry plots are representative of a biological replicate from three independent experiments. Bar graphs in A–C display mean ± SD values across triplicate samples. p Values were calculated using the two-tailed Student's t test. *p < 0.05; **p < 0.01. Andrea Pennati et al. J. Neurosci. 2016;36:12598-12610 ©2016 by Society for Neuroscience