Volume 59, Issue 1, Pages (January 2001)

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Volume 59, Issue 1, Pages 363-373 (January 2001) Kinetic studies of dipeptide-based and amino acid-based peritoneal dialysis solutions Andrzej Weryński, Jacek Waniewski, Tao Wang, Björn Anderstam, Bengt Lindholm, Jonas Bergström Kidney International Volume 59, Issue 1, Pages 363-373 (January 2001) DOI: 10.1046/j.1523-1755.2001.00499.x Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 1 Kinetic model of diffusive and convective transport of dipeptides and amino acids. Nomenclature is: VD, peritoneal volume; CDD and CBA, dialysate and blood dipeptide concentrations, respectively; CDA and CBA are concentrations of amino acids in dialysate and blood plasma, respectively; KH, the hydrolysis rate of dipeptide; KBDD and KBDA, diffusive mass transport rate coefficients of dipeptides and amino acids, respectively; QA, fluid absorption rate; QV, ultrafiltration flow rate. This model does not include exchanges between the blood and extravascular compartments. Kidney International 2001 59, 363-373DOI: (10.1046/j.1523-1755.2001.00499.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 2 Time courses of peritoneal volumes (VD) during dwell studies with the dipeptide-based solutions, Dip 16 (▪) and Dip 8 (♦), and with the amino acid-based solution (▴). Kidney International 2001 59, 363-373DOI: (10.1046/j.1523-1755.2001.00499.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 3 Examples of concentrations of dipeptides and constituent amino acids in dialysate during dwell studies with the strong dipeptide-based dialysis solution (Dip 16). DP and AA denote dipeptides and amino acids, respectively. Kidney International 2001 59, 363-373DOI: (10.1046/j.1523-1755.2001.00499.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 4 Relationship between diffusive mass transport coefficients for amino acids (KBDA, ♦) as well as dipeptides (KBDD, ▪) and molecular weight of corresponding amino acids or dipeptides. Kidney International 2001 59, 363-373DOI: (10.1046/j.1523-1755.2001.00499.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 5 Time courses of the concentration of one selected amino acid, histidine, in plasma during dwell studies with the Dip 16 (▪), Dip 8 (♦) solutions, and the amino acid-based (▴) solution. Kidney International 2001 59, 363-373DOI: (10.1046/j.1523-1755.2001.00499.x) Copyright © 2001 International Society of Nephrology Terms and Conditions