Acute Stress Increases Intraocular Pressure in Nonhuman Primates

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Acute Stress Increases Intraocular Pressure in Nonhuman Primates Daniel C. Turner, PhD, Michelle Miranda, PhD, Jeffrey S. Morris, PhD, Christopher A. Girkin, MD, MSPH, J. Crawford Downs, PhD, FARVO Ophthalmology Glaucoma DOI: 10.1016/j.ogla.2019.03.010 Copyright © 2019 American Academy of Ophthalmology Terms and Conditions

Figure 1 Experiment summary: Intraocular pressure (IOP) and blood pressure (BP) elevation due to acute stress. Top: Experimental time course. Middle: Representative raw IOP and BP data before, during, and after anesthetic procedure in one session. Bottom: Relative change from baseline in mean IOP, mean arterial pressure (MAP), and heart rate (HR) before and during anesthetic induction (*P < 0.05). Ophthalmology Glaucoma DOI: (10.1016/j.ogla.2019.03.010) Copyright © 2019 American Academy of Ophthalmology Terms and Conditions

Figure 2 Continuous intraocular pressure (IOP), mean arterial pressure (MAP), and heart rate (HR) in 1 nonhuman primate (NHP) during a representative NHP housing room cleaning session. Top left: Table showing differences from baseline presented as percent difference from baseline measurements. Top middle: Mean IOP values during cleaning procedure. Top right: MAP and HR values during cleaning procedure. Bottom: Screenshot of raw telemetry data with each measurement period highlighted and labeled according to the table and charts (top). Baseline values were recorded before the animals had any contact with humans. Ophthalmology Glaucoma DOI: (10.1016/j.ogla.2019.03.010) Copyright © 2019 American Academy of Ophthalmology Terms and Conditions