Increased but ineffectual angiogenic drive in nonhealing venous leg ulcers Susan L Drinkwater, BSc, Kevin G Burnand, MS, Ren Ding, PhD, Alberto Smith,

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Increased but ineffectual angiogenic drive in nonhealing venous leg ulcers Susan L Drinkwater, BSc, Kevin G Burnand, MS, Ren Ding, PhD, Alberto Smith, PhD Journal of Vascular Surgery Volume 38, Issue 5, Pages 1106-1112 (November 2003) DOI: 10.1016/S0741-5214(03)01053-X

Fig 1 Vascular endothelial growth factor (VEGF) concentration in biopsy tissue homogenates. NH, Nonhealing venous ulcers; H, healing venous ulcers; LDS, previously healed venous ulcers; Skin, normal skin. Analysis was with ANOVA (P < .001), with Tukey multiple comparison test. Journal of Vascular Surgery 2003 38, 1106-1112DOI: (10.1016/S0741-5214(03)01053-X)

Fig 2 Vascular endothelial growth factor (VEGF) concentration in biopsy tissue homogenates shows distribution around ulcer. Analysis with ANOVA. Journal of Vascular Surgery 2003 38, 1106-1112DOI: (10.1016/S0741-5214(03)01053-X)

Fig 3 Correlation between vascular endothelial growth factor (VEGF) concentration (ng/mL soluble protein) in wound fluid and in biopsy tissue in samples collected simultaneously from same ulcer (n = 27). Analysis was with Spearman rank correlation. Journal of Vascular Surgery 2003 38, 1106-1112DOI: (10.1016/S0741-5214(03)01053-X)

Fig 4 Vascular endothelial growth factor (VEGF) concentration in fluid from nonhealing venous ulcers (NH), healing venous ulcers (H), and acute wounds (A). Bars represent mean values. Analysis was with ANOVA (P = .006), with multiple comparison test. Journal of Vascular Surgery 2003 38, 1106-1112DOI: (10.1016/S0741-5214(03)01053-X)

Fig 5 Vascular endothelial growth factor receptor-1 (VEGFR1) concentration in exudates from nonhealing venous ulcers (NH), healing venous ulcers (H), and acute wounds (A). Bars represent mean values. No significant difference was observed between any groups (ANOVA). Journal of Vascular Surgery 2003 38, 1106-1112DOI: (10.1016/S0741-5214(03)01053-X)

Fig 6 Relative intensity of band staining for Vascular endothelial growth factor165 (VEGF 165) expressed as ratio to band staining for GAPDH (housekeeping gene). NH, Edge of nonhealing ulcer; H, edge of healing ulcer; LDS, lipodermatosclerosis at site of previously healed ulcer. Bars represent mean values. Analysis was with ANOVA (P = .011), with Tukey multiple comparison test. Journal of Vascular Surgery 2003 38, 1106-1112DOI: (10.1016/S0741-5214(03)01053-X)