The Side Story of Stem-like Glioma Cells

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Presentation transcript:

The Side Story of Stem-like Glioma Cells Anders I. Persson, William A. Weiss Cell Stem Cell Volume 4, Issue 3, Pages 191-192 (March 2009) DOI: 10.1016/j.stem.2009.02.004 Copyright © 2009 Elsevier Inc. Terms and Conditions

Figure 1 Models to Describe How Loss of PTEN and Treatment with Temozolomide May Lead to Chemoresistance in Glioma (A) Loss of PTEN leads to increased ABCG2 activity (represented by black squares) in a subset of cells, resulting in increased self-renewal and net chemoresistance. (B) The alkylating agent temozolomide most effectively targets non-SP cells, leading to relative expansion of a chemoresistant (ABCG2-positive) SP fraction. Cell Stem Cell 2009 4, 191-192DOI: (10.1016/j.stem.2009.02.004) Copyright © 2009 Elsevier Inc. Terms and Conditions