CD8 T cell memory alters the immune profile in enhanced HLH without altering viral load. CD8 T cell memory alters the immune profile in enhanced HLH without.

Slides:

Advertisements

Similar presentations

Fig. 1. Antibody response in mice immunized with VLP. Three groups of mice (n=10/group) were used in this study. Mice in groups 1 and 2 were immunized.

Advertisements

Volume 17, Issue 5, Pages (May 2015)

Fig. 1. Level of Mac-1 expression on naive and recently activated LCMV GP33–41-specific T cells from TCR 318 transgenic mice. (A and B) Splenocytes from.

Volume 44, Issue 2, Pages (February 2016)

Initial T Cell Receptor Transgenic Cell Precursor Frequency Dictates Critical Aspects of the CD8+ T Cell Response to Infection Vladimir P. Badovinac,

Volume 36, Issue 6, Pages (June 2012)

Volume 8, Issue 2, Pages (February 1998)

Volume 27, Issue 4, Pages (October 2007)

Hans-Peter Raué, Carol Beadling, Jennifer Haun, Mark K. Slifka

Volume 25, Issue 11, Pages (November 2017)

miR-150-Mediated Foxo1 Regulation Programs CD8+ T Cell Differentiation

Viral Infection Results in Massive CD8+ T Cell Expansion and Mortality in Vaccinated Perforin-Deficient Mice Vladimir P Badovinac, Sara E Hamilton, John.

Volume 28, Issue 2, Pages (February 2008)

Lung Airway-Surveilling CXCR3hi Memory CD8+ T Cells Are Critical for Protection against Influenza A Virus Bram Slütter, Lecia L. Pewe, Susan M. Kaech,

Loss of Runx2 in the T cell compartment leads to a defect in the number of CD8+ memory precursor T cells during LCMV–Armstrong infection. Loss of Runx2.

Masanori Isogawa, Yoshihiro Furuichi, Francis V. Chisari Immunity

Volume 21, Issue 7, Pages (November 2017)

DKO CD8+ T cells demonstrate a strong effector response but altered memory differentiation and maintenance after LCMV infection. DKO CD8+ T cells demonstrate.

Volume 11, Issue 6, Pages (June 2012)

Volume 31, Issue 1, Pages (July 2009)

MP cells established in Rag γc KO mice are Toxoplasma antigen–unspecific T-bet+ population. MP cells established in Rag γc KO mice are Toxoplasma antigen–unspecific.

Prf1−/− mice exhibit increased immunopathology with prior CD8 T cell memory secondary to immunization. Prf1−/− mice exhibit increased immunopathology with.

Loss of pathogen-specific T cell memory is due to the absence of Runx2 in CD8+ T cells. Loss of pathogen-specific T cell memory is due to the absence of.

Altered cytokine production by Klrk1−/− NOD CTL

Protective Capacity of Memory CD8+ T Cells Is Dictated by Antigen Exposure History and Nature of the Infection Jeffrey C. Nolz, John T. Harty Immunity

Volume 33, Issue 1, Pages (July 2010)

Volume 21, Issue 9, Pages (November 2017)

Volume 17, Issue 3, Pages (October 2016)

Volume 11, Issue 6, Pages (June 2012)

Volume 29, Issue 6, Pages (December 2008)

Volume 40, Issue 5, Pages (May 2014)

An Interleukin-21- Interleukin-10-STAT3 Pathway Is Critical for Functional Maturation of Memory CD8+ T Cells Weiguo Cui, Ying Liu, Jason S. Weinstein,

Volume 35, Issue 4, Pages (October 2011)

Volume 32, Issue 1, Pages (January 2010)

Eric A Butz, Michael J Bevan Immunity

Volume 39, Issue 1, Pages (July 2013)

Volume 29, Issue 4, Pages (October 2008)

Volume 44, Issue 5, Pages (May 2016)

Volume 13, Issue 6, Pages (November 2015)

Volume 24, Issue 1, Pages (January 2016)

Cell-Intrinsic IL-27 and gp130 Cytokine Receptor Signaling Regulates Virus-Specific CD4+ T Cell Responses and Viral Control during Chronic Infection

Lisa P. Daley-Bauer, Grace M. Wynn, Edward S. Mocarski Immunity

Matthew A. Williams, Eugene V. Ravkov, Michael J. Bevan Immunity

Volume 27, Issue 2, Pages (August 2007)

Susan M. Kaech, Scott Hemby, Ellen Kersh, Rafi Ahmed Cell

Volume 17, Issue 5, Pages (May 2015)

Volume 32, Issue 1, Pages (January 2010)

Volume 16, Issue 12, Pages (September 2016)

MP cells can mediate resistance in infectious models that induce TH1-type immunity. MP cells can mediate resistance in infectious models that induce TH1-type.

Ag 85A–specific immune responses.

Volume 40, Issue 2, Pages (February 2014)

Volume 38, Issue 6, Pages (June 2013)

Volume 38, Issue 2, Pages (February 2013)

Antigen-specific immune responses are enhanced in hypertension.

Attrition of T Cell Memory

APCs from hypertensive mice present antigens more efficiently.

Non–viral Ag–specific CTLs dampen inflammation in a mouse model of viral meningitis. Non–viral Ag–specific CTLs dampen inflammation in a mouse model of.

Volume 31, Issue 2, Pages (August 2009)

Volume 8, Issue 2, Pages (July 2014)

Members of IL-1 family of cytokines favor the generation of IL-3–secreting CD4+ T cells in vitro. Members of IL-1 family of cytokines favor the generation.

Characteristics of GM-CSF–secreting CD4+ T cells.

Figure 3. Enhancement of cytokine production by CD8+ T cells at TT

Sustained T follicular helper cell response is essential for control of chronic viral infection by Ute Greczmiel, Nike Julia Kräutler, Alessandro Pedrioli,

Volume 9, Issue 3, Pages (March 2011)

Sang Kyun Ahn, Vanessa Tran, Andrea Leung, Mark Ng, Ming Li, Jun Liu

B- and T-cell activity induced by immunization.

Hypoxic Ag-specific CD8+ T cells are less functional and less proliferative. Hypoxic Ag-specific CD8+ T cells are less functional and less proliferative.

Supplementary Figure 1. The extrinsic acquisition of CD80 does not affect the cytotoxicity of Ag-specific memory CD8+ T cells. The LG and SP were obtained.

Volume 8, Issue 2, Pages (August 2010)

Immunization with IR or F/T elicits activated OT-I cells of distinct phenotypes. Immunization with IR or F/T elicits activated OT-I cells of distinct phenotypes.

Presentation transcript:

CD8 T cell memory alters the immune profile in enhanced HLH without altering viral load. CD8 T cell memory alters the immune profile in enhanced HLH without altering viral load. Prf1−/− mice were immunized against gp33 or control, rested for 30 d, and infected with LCMV. Mice were sacrificed on day 7 postinfection, serum samples were obtained, and splenocytes were stimulated in vitro and analyzed. (A) Serum cytokine levels in immunized and control mice (n = 8–12). (B) Total gp33-specific CD8 T cells (CD90+, CD8+, CD44+, IFN-γ+) in immunized and control mice determined by IFN-γ production following in vitro stimulation (n = 6–8). Total number of gp33-specific CD8 T cells determined by gp33 tetramer staining (CD90+, CD8+, CD44+, gp33 tetramer+) (n = 6–7). (C) Percent of total CD8 T cells specific for gp33 or NP396 determined by IFN-γ production following in vitro peptide stimulation with the respective peptide in gp33 immunized and control mice on day 7 postinfection (CD90+, CD8+, CD44+, IFN-γ+) (n = 4). (D) Then 7 d post–LCMV infection, total number of gp33-specific TNF-α–producing splenic CD8 T cells (CD90+, CD8+, CD44+, TNF-α+) following in vitro peptide stimulation (n = 6–8). (E) LCMV splenic titers (n = 6–8). Log scale is shown. All plots representative of a minimum of two experimental replicates. *p < 0.05 by two-way Student t test. Matthew D. Taylor et al. ImmunoHorizons 2018;2:67-73 Copyright © 2018 The Authors