David S. Southam, BSc, Natasha Widmer, Russ Ellis, BSc, Jeremy A

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Presentation transcript:

Increased eosinophil-lineage committed progenitors in the lung of allergen-challenged mice David S. Southam, BSc, Natasha Widmer, Russ Ellis, BSc, Jeremy A. Hirota, BSc, Mark D. Inman, MD, PhD, Roma Sehmi, PhD Journal of Allergy and Clinical Immunology Volume 115, Issue 1, Pages 95-102 (January 2005) DOI: 10.1016/j.jaci.2004.09.022 Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 Hypothesized role of bone marrow progenitor cells in the development of ongoing airway eosinophilia. Journal of Allergy and Clinical Immunology 2005 115, 95-102DOI: (10.1016/j.jaci.2004.09.022) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 Flow-cytometric enumeration of the time course of the absolute number of lung extracted total (CD34+CD45+) progenitor cells, eosinophil-lineage committed (CD34+CD45+IL-5Rα+) progenitor cells, and proportion of lung extracted CD34+CD45+IL-5Rα+ per CD34+CD45+ after airway ovalbumin challenge (mean ± SEM). n=8-10/group. ∗P < .05 compared with saline (SAL) control at 24-hour time point. Journal of Allergy and Clinical Immunology 2005 115, 95-102DOI: (10.1016/j.jaci.2004.09.022) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 3 Eosinophils plucked from colony-forming units (CFUs) plated from 1.4 × 105 lung cells from saline-perfused mouse lung tissue extracted 6 hours after brief ovalbumin sensitization and challenge protocol and incubated for 10 days with 10 ng/mL IL-5. Journal of Allergy and Clinical Immunology 2005 115, 95-102DOI: (10.1016/j.jaci.2004.09.022) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 4 BAL eosinophils after airway ovalbumin challenge (mean ± SEM). n=4-11/group. ∗P < .00625 compared with saline (SAL) control at 24-hour time point. Journal of Allergy and Clinical Immunology 2005 115, 95-102DOI: (10.1016/j.jaci.2004.09.022) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 5 IL-5, eotaxin, and SDF-1α ELISA of BAL fluid at various time points after airway ovalbumin challenge (mean ± SEM). n=7-10/group. ∗P < .05 compared with saline (SAL) control at 24-hour time point. Journal of Allergy and Clinical Immunology 2005 115, 95-102DOI: (10.1016/j.jaci.2004.09.022) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 6 Flow-cytometric enumeration of the time course of the absolute number of BM extracted total (CD34+CD45+) progenitor cells, eosinophil-lineage committed (CD34+CD45+IL-5Rα+) progenitor cells, and proportion of BM extracted CD34+CD45+IL-5Rα+ per CD34+CD45+ after airway ovalbumin challenge (mean ± SEM). n=8-10/group. ∗P < .05 compared with saline (SAL) control at 24-hour time point. Journal of Allergy and Clinical Immunology 2005 115, 95-102DOI: (10.1016/j.jaci.2004.09.022) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions