A: Comparison of the glucose-dependent insulinotropic effects of efaroxan and phentolamine. A: Comparison of the glucose-dependent insulinotropic effects.

Slides:

Advertisements

Similar presentations

Mechanisms of Glucose Lowering of Dipeptidyl Peptidase-4 Inhibitor Sitagliptin When Used Alone or With Metformin in Type 2 Diabetes A double-tracer study.

Advertisements

Choosing a test of glucose metabolism in mice.

The 75 g glucose loading test.

Study design. Study design. Each subject with or without type 2 diabetes participated in euglycemic and hypoglycemic clamp visits separated by 4–8 weeks.

Mean daily glucose concentration and frequency of hypoglycemia in long-term care residents with type 2 diabetes. Mean daily glucose concentration and frequency.

Glucose-stimulated insulin secretion in virus-infected human islets.

Whole-body glucose kinetics in C and T2D-O during postabsorptive and clamp states. Whole-body glucose kinetics in C and T2D-O during postabsorptive and.

Cyp8b1−/− mice have improved islet insulin secretion and increased islet insulin content but unchanged β-cell mass. Cyp8b1−/− mice have improved islet.

NOx ASR (in mmol/day), arginine Ra (in µmol/kg × min), the fraction of arginine flux converted to NOx (%), and the insulin-mediated glucose disposal (M)

Serial measurements of serum glucose, anion gap, serum carbon dioxide, and serum triglycerides throughout the patient's hospital stay. Serial measurements.

A: PPG increment at week 26 for mealtime faster aspart versus IAsp.

Comparison of the protective effects of R and S isomers of LA on insulin-stimulated 2-DG uptake. Comparison of the protective effects of R and S isomers.

Liver mitochondrial protein FSR

Glucose, insulin, and AGE levels during an OGC before and after RT

Involvement of IRS-1 in L-783,281–stimulated increases in [Ca2+]i and exocytosis. Involvement of IRS-1 in L-783,281–stimulated increases in [Ca2+]i and.

(A) Glucose values (mean +SEM) during continuous glucose monitoring while consuming whey protein (solid lines and filled circles) or placebo (broken lines.

Decreased GLP-1 receptor expression in islets after exposure to high glucose. Decreased GLP-1 receptor expression in islets after exposure to high glucose.

1018-NT-β-cell clusters protect mice from STZ-induced diabetes.

WASH cKO mice display a normal pancreatic development.

GSIS. GSIS. In vivo: serum insulin levels at fasting state and 30 min after glucose injection (A) and the fold change in serum insulin after glucose loading.

Activation of β-adrenoceptors improves glucose tolerance in diabetic animals and increases glucose uptake in vivo, ex vivo, and in vitro. Activation of.

Effect of PIs on insulin release by downstream insulin secretogogues.

PTx pretreatment abrogates the glucagonostatic effect of high glucose concentrations. PTx pretreatment abrogates the glucagonostatic effect of high glucose.

Models of the mechanisms by which sulfonylureas and glucose control glucagon release. Models of the mechanisms by which sulfonylureas and glucose control.

In the absence of SST, 20 or 30 mmol/L glucose stimulates glucagon release. In the absence of SST, 20 or 30 mmol/L glucose stimulates glucagon release.

Glycemia and glucose tolerance of RIP-N mice.

Attenuation of glucose-, ex-4–, and GIP-induced increases in NSCC current in β-cells from TRPM2-KO mice. Attenuation of glucose-, ex-4–, and GIP-induced.

Comparison of the regression lines for AIRarg (the acute insulin response to intravenous arginine over 2–5 min after injection) and AIRargMAX (the response.

Mean ± SEM concentration of insulin in plasma and CSF and glucose in plasma 30 min after the intraperitoneal administration of DET or NPH insulin at different.

Plasma growth hormone concentrations during a 65-min infusion of acyl ghrelin at 0.3, 0.9, or 1.5 nmol/kg/h, or saline. Plasma growth hormone concentrations.

Zn2+ and NAD(P)H content in Mafa∆panc and Mafa∆panc;Mafb+/− β-cells.

Measurement of insulin release from islets evoked by glucose, diazoxide, and high K+. Measurement of insulin release from islets evoked by glucose, diazoxide,

Effects of in vivo AICAR treatment on blood glucose and lactate concentrations. Effects of in vivo AICAR treatment on blood glucose and lactate concentrations.

DHA suppresses the translocation of NFκB and ROS generation stimulated by excess glucose and palmitate. 3T3–L1 adipocytes were cultured in 5 or 25 mmol/l.

Somatostatin released by δ-cells exerts a tonic inhibition on glucagon and insulin secretion but is not required for the glucagonostatic effect of glucose.

Effect of blockade of the Fas receptor on glucose- and interleukin-1β–induced β-cell DNA fragmentation and proliferative activity. Effect of blockade of.

FFAs have differential effects on NFκB translocation and ROS generation. 3T3–L1 adipocytes differentiated in 5 or 25 mmol/l glucose were cultured on glass.

Extracellular Ca2+-dependent cAMP production.

Interacting effects of 22(R)-hydroxycholesterol and 9-cis-RA with fatty acids and ketone bodies on the expression of ABCA1 in HepG2 cells and RAW264.7.

Substrate oxidation and contractile performance of Akita hearts

Upregulation of Kv2.1 in human T2D β-cells improves exocytotic function. Upregulation of Kv2.1 in human T2D β-cells improves exocytotic function. Knockdown.

Npas4 induction is cytoprotective for pancreatic β-cells.

GLP-1 and gastrin combination therapy restores normoglycemia in NOD mice. GLP-1 and gastrin combination therapy restores normoglycemia in NOD mice. Beginning.

A: Chemical structure of pterosin A

Involvement of PKCα in downregulation of GLP-1 receptor by high glucose in isolated rat islets. Involvement of PKCα in downregulation of GLP-1 receptor.

Supplementation of c-Rel–competent Treg cells reverts exacerbated diabetes in c-Rel−/− NOD mice. Supplementation of c-Rel–competent Treg cells reverts.

Glucose stimulates GLP-1 secretion from the perfused rat intestine by a dose- and absorption-dependent manner. Glucose stimulates GLP-1 secretion from.

Plasma concentrations of glucose, insulin, C-peptide and glucagon observed in subjects with NFG/NGT, NFG/IGT, IFG/NGT, and IFG/IGT-D following ingestion.

The lack of effect of denatonium to stimulate insulin release in the absence of extracellular Ca2+ or in the presence of 10 μmol/l nitrendipine. The lack.

Mean (±SE) plasma glucose concentrations before, during, and after infusions of octreotide (with growth hormone) with saline (•), with insulin replacement.

Npas4 is a stress-induced factor in pancreatic β-cells.

Functional promoter activity of the human COX-2 gene in HMCs

An anti-BTC neutralizing antibody and a metalloproteinase inhibitor suppress GLP-1-induced DNA synthesis in INS(832/13) cells. [3H]thymidine incorporation.

Assay of ROS accumulation in cells exposed to high levels of glucose.

Oral glucose tolerance testing during hospitalization and at 4 months after infarction. Oral glucose tolerance testing during hospitalization and at 4 months.

PKA inhibitors do not markedly affect the potentiation of glucose-induced insulin release by GLP-1. PKA inhibitors do not markedly affect the potentiation.

RT-PCR quantification of ubiquitination gene transcripts in rat islets exposed to 2.8 or 16.7 mmol/l glucose for 2 h (A) or 24 h (B). RT-PCR quantification.

Pioglitazone administration acutely inhibits insulin secretion and increases insulin clearance in Wistar rats. Pioglitazone administration acutely inhibits.

Increased pancreatic insulin content and islet size and protection against HFD- and palmitate-induced cell death in PKCδKN-overexpressing mice. Increased.

Chronic rapamycin treatment impairs β-cell mass and insulin clearance in rats. Chronic rapamycin treatment impairs β-cell mass and insulin clearance in.

Blood glucose levels in chicken embryos.

ADCY5 targets nonmetabolic processes to alter Ca2+ responses.

Mice lacking Y1 receptor in the hematopoietic compartment remain healthy under normal chow feeding conditions. Mice lacking Y1 receptor in the hematopoietic.

ADCY5 is expressed in isolated human islets and affected by T2D risk alleles. ADCY5 is expressed in isolated human islets and affected by T2D risk alleles.

Correlations between leptin DNA methylation and 2-h post-OGTT glucose levels, within the IGT group (A and B), leptin DNA methylation and mRNA levels (C.

Median (interquartile range) of sensor glucose (A) and insulin delivery (B) during closed-loop (solid red line and red shaded area) and control period.

(A) Twenty-four-hour plasma profiles of insulin and amylin in healthy subjects. (A) Twenty-four-hour plasma profiles of insulin and amylin in healthy subjects.

A: Diet-specific postprandial responses to glucose and NEFA levels.

Four–time point diurnal profiles of plasma glucose concentrations (A) and AUCs (B) over quintiles of HbA1c. ○, AUC1; •, AUC2; ▴, AUC2 − AUC1 (differences.

Cumulative mean numbers of confirmed (plasma glucose ≤3

Presentation transcript:

A: Comparison of the glucose-dependent insulinotropic effects of efaroxan and phentolamine. A: Comparison of the glucose-dependent insulinotropic effects of efaroxan and phentolamine. Freshly isolated mouse islets were perifused with a Krebs-Ringer medium containing 5 mmol/l glucose from min 0 to min 90. Then the glucose concentration was raised to 10 mmol/l from min 90 to min 130. Either 100 μmol/l efaroxan (•) or 100 μmol/l phentolamine (○) was present from min 60 to 120. □, the effect of 5 and 10 mmol/l glucose alone. Values are means ± SEM of four experiments. B: Effect of raising glucose concentration from 5 to 20 mmol/l. The secretory rate in 20 mmol/l glucose is about twice that evoked by 10 mmol/l glucose in the presence of efaroxan. Note that the kinetics of the first-phase increases are similar. Values are means ± SEM of three experiments. Claudia Bleck et al. Diabetes 2004;53:S135-S139 ©2004 by American Diabetes Association