HFD feeding induced insulin resistance in TRIB3 MOE mice.

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HFD feeding induced insulin resistance in TRIB3 MOE mice. HFD feeding induced insulin resistance in TRIB3 MOE mice. A: TRIB3 MOE mice developed significantly heavier BW after 16 weeks of the HFD. Fasting glucose (B), insulin (C), cholesterol (D), and triglyceride (E) levels in control and TRIB3 MOE mice (n = 6). F: TRIB3 MOE mice exhibited significantly impaired glucose tolerance on glucose tolerance test (GTT; glucose 2 g/kg BW, i.p.) under high-fat feeding (n = 7). G: TRIB3 MOE mice developed significantly impaired insulin sensitivity as reflected by ITT (Humalog, 0.5 units/kg BW, i.p.; n = 7). H: Western blot analysis of insulin-signaling proteins in muscle tissue collected after 30 min of insulin injection (Humalog, 0.5 units/kg BW, i.p.; n = 3). HFD led to obviously impaired insulin signal transduction in skeletal muscle of TRIB3 MOE mice, including decreased p-GSK3 α/β, p-AKT(308), p-AKT (473), and p-AMPK-α (n = 3). Data are means ± SEM. *P < 0.05 and **P < 0.01 vs. control group by two-way ANOVA. Wei Zhang et al. Diabetes 2016;65:2380-2391 ©2016 by American Diabetes Association