Motif enrichment analysis of p42, common, and p30 CEBPA-bound regions

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Fig. 2 Motif enrichment analysis of p42, common, and p30 CEBPA-bound regions. Motif enrichment analysis of p42, common, and p30 CEBPA-bound regions. (A) TF motif enrichment analysis, combining results from three TF motif databases. The set of common regions is used as reference, and the relative enrichment z scores for p42 and p30 regions (compared to common) are displayed as shades of orange (enriched) or blue (depleted). (B) Percentages of CEBPA-bound regions overlapping with regions bound by ERG, FLI1, and PU1 in the HPC-7 cell line. (C) Proteomics quantification of TFs with enriched motifs, comparing FACS isolated WT GMPs and Lp30 L-GMPs (Limma multifactorial analysis, Benjamini-Hochberg corrected P value. *P ≤ 0.05; **P ≤ 0.01). (D) RNA-seq quantification of TF gene expression with enriched motifs, comparing WT GMPs and Lp30 L-GMPs (RNA-seq, *FDR ≤ 0.05; ****FDR ≤ 0.0001). (E) RT-qPCR quantification of Cebpa expression normalized to Actg1 (WT GMPs, n = 3; Lp30 L-GMPs, n = 7, Student’s t test. ***P < 0.001). (F) CEBPA Western blot using WT GMPs and Lp30 L-GMPs. The CEBPA and Histone H3 bands were obtained from the same blot incubated with different Abs. (G) All CEBPA motifs found in p42, common, and p30 region sets tested for their match to the CEBPA consensus (Jasper DB. One-tailed Wilcoxon test. **P ≤ 0.001). (H) Frequencies of bins of CEBPA-consensus matching motifs in each region set. Janus S. Jakobsen et al. Sci Adv 2019;5:eaaw4304 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).