Absence of OcaB protects against age-induced insulin resistance.

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Absence of OcaB protects against age-induced insulin resistance. Absence of OcaB protects against age-induced insulin resistance. A and B: Intraperitoneal glucose tolerance test in 2-month-old (A) and 6-month-old (B) OcaB+/+ and OcaB−/− mice (n = 11–13/group). C and D: Insulin tolerance test in 2-month-old (C) and 6-month-old (D) OcaB+/+ and OcaB−/− mice (n = 11–13/group). E–H: Rates of glucose infusion (E), glucose disposal (Rd) (F), glucose appearance (Ra) (G), and glucose uptake (H) in 6-month-old OcaB+/+ and OcaB−/− mice (n = 5–6/group) during a euglycemic-hyperinsulinemic clamp consisting of a 5-μCi bolus of D-[3-3H]glucose given at the beginning, followed by infusion of 0.05 μCi/min during a 90-min tracer equilibration period. The clamp then began with a primed continuous infusion of human insulin (a bolus of 16 mU/kg body weight followed by 4 mU/kg body weight/min). The D-[3-3H]glucose infusion was increased to 0.2 μCi/min for the rest of the 120-min experimental period. Euglycemia was achieved by infusing a 20% dextrose solution as necessary. *P < 0.05; ***P < 0.0001. GIR, glucose infusion rate; KO, knockout (OcaB−/−); WT, wild type (OcaB+/+ littermates). Sophie Carter et al. Diabetes 2018;67:1285-1296 ©2018 by American Diabetes Association