Rame A. Taha, MDa, Eleanor M. Minshall, PhDa, Donald Y. M

Slides:

Advertisements

Similar presentations

Assessment of inflammation in noninfectious chronic maxillary sinusitis Pascal Demoly, MDa, Louis Crampette, MDb, Michel Mondain, MDb, Alison M. Campbell,

Advertisements

W.Travis Cain, MDa, Greg Cable, PhDb, John J. Oppenheimer, MDc

Relationship of nasal carriage of Staphylococcus aureus to pathogenesis of perennial allergic rhinitis Teruo Shiomori, MDa, Shin-ichi Yoshida, MD, PhDb,

Response to cyclosporin and low-dose methylprednisolone in aggressive systemic mastocytosis Motohiro Kurosawa, MD, PhD, PharmDa, Hiroo Amano, MD, PhDb,

Different expression of cytokine and membrane molecules by circulating lymphocytes on acute mental stress in patients with atopic dermatitis in comparison.

Gene expression of vascular endothelial growth factor and its receptors and angiogenesis in bronchial asthma Makoto Hoshino, MDa, Yutaka Nakamura, MDa,

Eosinophil cationic protein and histamine after intestinal challenge in patients with cow's milk intolerance Ulf Bengtsson, MD, PhDa, Tina W. Knutson,

A randomized, vehicle-controlled trial of tacrolimus ointment for treatment of atopic dermatitis in children Mark Boguniewicz, MDa, Virginia C. Fiedler,

Atopic dermatitis: Age and race do matter!

Predominance of type 2 cytokine–producing CD4+ and CD8+ cells in patients with atopic dermatitis Masatoshi Nakazawa, DVMa, Nakako Sugi, MDb, Hiroshi.

Airway epithelial cells in asthma

Evidence for a role for IL-5 and eotaxin in activating and recruiting eosinophils in drug- induced cutaneous eruptions Nikhil Yawalkar, MD, Maithili Shrikhande,

Asthma and increased bronchial responsiveness in elite athletes: Atopy and sport event as risk factors Ilkka J. Helenius, MDa, Heikki O. Tikkanen, MDb,

The effect of omalizumab on nasal allergic inflammation

Youngil I. Koh, MD a, Inseon S

Grass pollen immunotherapy inhibits allergen-induced infiltration of CD4+ T lymphocytes and eosinophils in the nasal mucosa and increases the number of.

Chronic sinusitis in severe asthma is related to sputum eosinophilia

Pathophysiology of severe asthma

Inflammation of small airways in asthma

Oral corticosteroids decrease eosinophil and CC chemokine expression but increase neutrophil, IL-8, and IFN-γ–inducible protein 10 expression in asthmatic.

Chronologic analysis of in situ cytokine expression in mite allergen-induced dermatitis in atopic subjects Nobuo Yamada, MDa, Motoshi Wakugawa, MDa,

IL-11 expression is increased in severe asthma: Association with epithelial cells and eosinophils Eleanor Minshall, PhDa, Jamila Chakir, PhDb, Michel.

Measurement of airborne mite allergen exposure in individual subjects

Expression and localization of histamine H2 receptor messenger RNA in human nasal mucosa Noriko Hirata, MDa, Kazuhiko Takeuchi, MDa, Kotaro Ukai, MDa,

Expression of IFN-γ–inducible protein; monocyte chemotactic proteins 1, 3, and 4; and eotaxin in TH1- and TH2-mediated lung diseases Deborah Miotto,

Evidence for expression of eosinophil-associated IL-12 messenger RNA and immunoreactivity in bronchial asthma Esra Nutku, MDa, Abdelilah Soussi Gounni,

Fluticasone propionate aqueous nasal spray reduces inflammatory cells in unchallenged allergic nasal mucosa: Effects of single allergen challenge Adriaan.

Inflammatory cells, cytokine and chemokine expression in asthma immunocytochemistry and in situ hybridization Qutayba Hamid, MD, PhD, Editor Journal.

Recruitment of T cells to the lung in response to antigen challenge

Effect of ozone and nitrogen dioxide on the release of proinflammatory mediators from bronchial epithelial cells of nonatopic nonasthmatic subjects and.

Inflammatory cell and epithelial characteristics of perennial allergic and nonallergic rhinitis with a symptom history of 1 to 3 years’ duration Kawa.

Molecular virology and immunology of HIV infection

Nasal eosinophilia and IL-5 mRNA expression in seasonal allergic rhinitis induced by natural allergen exposure: Effect of topical corticosteroids Keisuke.

Gross pathology and histopathology of asthma

Classification of anti-FcϵRI and anti-IgE autoantibodies in chronic idiopathic urticaria and correlation with disease severity Ruth A. Sabroe, MDa, Edda.

Vascular endothelial growth factor in patients with acute asthma

IL-9 expression by human eosinophils: Regulation by IL-1β and TNF-α

Basophil and eosinophil accumulation and mast cell degranulation in the nasal mucosa of patients with hay fever after local allergen provocation Alex.

Donald Y.M. Leung, MD, PhD Journal of Allergy and Clinical Immunology

T-cell cytokines in chronic allergic eye disease

TH1/TH2 cytokines and inflammatory cells in skin biopsy specimens from patients with chronic idiopathic urticaria: Comparison with the allergen-induced.

Thymus and activation-regulated chemokine in atopic dermatitis: Serum thymus and activation-regulated chemokine level is closely related with disease.

Increased serum cutaneous T cell-attracting chemokine (CCL27) levels in patients with atopic dermatitis and psoriasis vulgaris Takashi Kakinuma, MDa,

Assessment of inflammation in noninfectious chronic maxillary sinusitis Pascal Demoly, MDa, Louis Crampette, MDb, Michel Mondain, MDb, Alison M. Campbell,

The 30th anniversary of the American Board of Allergy and Immunology: Then and now Lynn Des Prez a, Charles E. Reed, MD, Lawrence B. Schwartz, MDb, John.

Molecular pathology of allergic disease

Blood eosinophils from atopic donors express messenger RNA for the α, β, and γ subunits of the high-affinity IgE receptor (FcϵRI) and intracellular, but.

Renata J. M. Engler, MDa, Julie Kenner, MD, PhDb, Donald Y. M

The Editors' Choice Journal of Allergy and Clinical Immunology

Seasonal intestinal inflammation in patients with birch pollen allergy

Prognosis and prediction of response to surgery in allergic patients with chronic sinusitis François Lavigne, MDa, Cong Thu Nguyen, MDa, Lisa Cameron,

A case of acute eosinophilic pneumonia with hypersensitivity to “red spider” allergens Bertrand Godeau, MDa, Laurent Brochard, MDb, Ioanis Theodorou,

Fibronectin and fibrinogen contribute to the enhanced binding of Staphylococcus aureus to atopic skin Sang-Hyun Cho, MDa, Ian Strickland, MPhila, Mark.

Changes in sputum counts and airway hyperresponsiveness after budesonide: Monitoring anti-inflammatory response on the basis of surrogate markers of airway.

Determinants of systemic manifestations of food allergy

Monocyte chemotactic proteins in allergen-induced inflammation in the nasal mucosa: Effect of topical corticosteroids Pota Christodoulopoulos, BSca,

Local expression of ϵ germline gene transcripts and RNA for the ϵ heavy chain of IgE in the bronchial mucosa in atopic and nonatopic asthma Sun Ying,

Cytokine profile in minor salivary glands from patients with bronchial asthma Anne Tsicopoulos, MDa, b, Anne Janin, MDc, Hikmat Akoum, PhDa, Catherine.

IL-4– and IL-5–positive T lymphocytes, eosinophils, and mast cells in allergen-induced late-phase cutaneous reactions in atopic subjects Luis T. Barata,

Clinical and immunologic variables in skin of patients with atopic eczema and either positive or negative atopy patch test reactions Elisabeth G. Langeveld-Wildschut,

Advances in allergic skin diseases

Cytokine modulation of atopic dermatitis filaggrin skin expression

Relationship of nasal carriage of Staphylococcus aureus to pathogenesis of perennial allergic rhinitis Teruo Shiomori, MDa, Shin-ichi Yoshida, MD, PhDb,

David A. Groneberg, MDab, Pia Welker, PhDcd, Tanja C. Fischer, MDc, Q

Airway remodeling-associated mediators in moderate to severe asthma: Effect of steroids on TGF-β, IL-11, IL-17, and type I and type III collagen expression

IL-31 is associated with cutaneous lymphocyte antigen–positive skin homing T cells in patients with atopic dermatitis Janine Bilsborough, PhD, Donald.

Immunopathology of atopic dermatitis

Differences in airway remodeling between subjects with severe and moderate asthma Carmela Pepe, MD, Susan Foley, MD, Joanne Shannon, MD, Catherine Lemiere,

Myosin light chain kinase mediates eosinophil chemotaxis in a mitogen-activated protein kinase–dependent manner Tetsuya Adachi, MDa, Susan Stafford,

Chitinases and chitinase-like proteins in TH2 inflammation and asthma

Presentation transcript:

Evidence for increased expression of eotaxin and monocyte chemotactic protein-4 in atopic dermatitis Rame A. Taha, MDa, Eleanor M. Minshall, PhDa, Donald Y.M. Leung, MD, PhDb, Mark Boguniewicz, MDb, Andrew Luster, MD, PhDc, Shigeo Muro, MDa, Masdo Toda, MDa, Qutayba A. Hamid, MD, PhDa Journal of Allergy and Clinical Immunology Volume 105, Issue 5, Pages 1002-1007 (May 2000) DOI: 10.1067/mai.2000.106483 Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 1 A, Representative examples of ISH of eotaxin mRNA in epidermal layer (E) of skin obtained from subjects with chronic AD subjects with use of digoxigenin-labeled antisense probe (phase contrast; original magnification ×400). Also note that there were some eotaxin mRNA-labeled antisense probe positive cells within the subepithelial layer (arrow). B, Negative control from chronic AD subjects with use of digoxigenin-labeled sense probe. Journal of Allergy and Clinical Immunology 2000 105, 1002-1007DOI: (10.1067/mai.2000.106483) Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 2 Expression of eotaxin and MCP-4 mRNA within the epidermal cell layer. Specific antisense digoxigenin riboprobes were used to identify eotaxin and MCP-4 mRNA-positive cells in skin biopsy specimens from acute and chronic AD lesions, uninvolved AD skin, and normal skin by ISH. Results are expressed as the percentage positive cells of the total epidermal cell layer. Filled symbols, Data for individual patients. Journal of Allergy and Clinical Immunology 2000 105, 1002-1007DOI: (10.1067/mai.2000.106483) Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 3 Expression of eotaxin and MCP-4 mRNA within the subepithelial cell layer. Specific antisense digoxigenin riboprobes were used to identify eotaxin and MCP-4 mRNA-positive cells in skin biopsy specimens from acute and chronic AD lesions, uninvolved AD skin, and normal skin by ISH. Results are expressed as numbers of positive cells per HPF (0.202 cm2). Filled symbols, Data for individual patients. Journal of Allergy and Clinical Immunology 2000 105, 1002-1007DOI: (10.1067/mai.2000.106483) Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 4 Relationship between eotaxin expression within the epidermal cell layer and numbers of resident eosinophils in chronic (filled circles) and acute (filled squares) AD skin lesions and uninvolved skin from patients with AD (filled triangles). There was a significant positive association observed (r 2 = 0.84, P < .05). Journal of Allergy and Clinical Immunology 2000 105, 1002-1007DOI: (10.1067/mai.2000.106483) Copyright © 2000 Mosby, Inc. Terms and Conditions