Exosome-mediated inhibition of T cells is reversible.

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Presentation transcript:

Exosome-mediated inhibition of T cells is reversible. Exosome-mediated inhibition of T cells is reversible. NDPBLs were activated with immobilized antibodies to CD3 and CD28 in the absence (Act) or presence (Act + Exo) of exosomes derived from ovarian tumor ascites fluid. These cells were then rested for 24 or 48 hours and reactivated in the absence of exosomes. Activation was then determined by monitoring NFκB translocation to the nucleus of CD3+ cells using fluorescence microscopy (A) or intracellular expression of IFNγ in CD4+ and CD8+ T cells using flow cytometry (B). The compiled mean ± SEM from three independent experiments is shown. NS, not significant; **, P < 0.01; ***, P < 0.001. Gautam N. Shenoy et al. Cancer Immunol Res 2018;6:236-247 ©2018 by American Association for Cancer Research