Age-related differences in the pathogenesis of chronic rhinosinusitis

Slides:

Advertisements

Similar presentations

Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing Danielle C.M. Belgrave, MSc,

Advertisements

A bioinformatics approach to identify patients with symptomatic peanut allergy using peptide microarray immunoassay Jing Lin, PhD, Francesca M. Bruni,

Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy Yitzhak Katz, MD, Nelly Rajuan, MSc, Michael R. Goldberg,

Transient receptor potential vanilloid 1 (TRPV1) antagonism in patients with refractory chronic cough: A double-blind randomized controlled trial Saifudin.

Characteristics of childhood peanut allergy in the Australian Capital Territory, 1995 to 2007 Raymond James Mullins, MBBS, PhD, FRACP, FRCPA, Keith B.G.

Endoplasmic reticulum stress influences bronchial asthma pathogenesis by modulating nuclear factor κB activation So Ri Kim, MD, PhD, Dong Im Kim, MS, Mi.

Lower vitamin D status is closely correlated with eczema of the head and neck Seongmin Noh, MD, Chang Ook Park, MD, Jung Min Bae, MD, Jungsoo Lee, MD,

D-dimer: A biomarker for antihistamine-resistant chronic urticaria

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD

Proton pump inhibitors decrease eotaxin-3/CCL26 expression in patients with chronic rhinosinusitis with nasal polyps: Possible role of the nongastric.

Anju T. Peters, MD, Atsushi Kato, PhD, Ning Zhang, PhD, David B

Genetic variation in B cell–activating factor of the TNF family (BAFF) and asthma exacerbations among African American subjects Rajesh Kumar, MD, MS,

Lower vitamin D status is closely correlated with eczema of the head and neck Seongmin Noh, MD, Chang Ook Park, MD, Jung Min Bae, MD, Jungsoo Lee, MD,

Endotype-driven care pathways in patients with chronic rhinosinusitis

Proton pump inhibitors decrease eotaxin-3/CCL26 expression in patients with chronic rhinosinusitis with nasal polyps: Possible role of the nongastric.

Heterogeneous inflammatory patterns in chronic rhinosinusitis without nasal polyps in Chicago, Illinois Bruce K. Tan, MD, MS, Aiko I. Klingler, PhD,

Evidence for intranasal antinuclear autoantibodies in patients with chronic rhinosinusitis with nasal polyps Bruce K. Tan, MD, Quan-Zhen Li, PhD, Lydia.

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Robert M. Naclerio, MD, Jayant Pinto, MD, Fuad Baroody, MD

Anju T. Peters, MD, Atsushi Kato, PhD, Ning Zhang, PhD, David B

Chronic Rhinosinusitis

Is 9 more than 2 also in allergic airway inflammation?

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD

Evidence of a role for B cell–activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps Atsushi Kato, PhD,

Oncostatin M promotes mucosal epithelial barrier dysfunction, and its expression is increased in patients with eosinophilic mucosal disease Kathryn L.

Evidence for altered levels of IgD in the nasal airway mucosa of patients with chronic rhinosinusitis Jin-Young Min, MD, PhD, Jayakar V. Nayak, MD, PhD,

Reply The Journal of Allergy and Clinical Immunology: In Practice

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Increased expression of CC chemokine ligand 18 in patients with chronic rhinosinusitis with nasal polyps Sarah Peterson, MD, Julie A. Poposki, MS, Deepti.

Griet A. Van Roey, PhD, Christopher C

RAGE processing in chronic airway conditions: Involvement of Staphylococcus aureus and ECP Koen Van Crombruggen, PhD, Gabriele Holtappels, Natalie De.

Cross-talk between human mast cells and epithelial cells by IgE-mediated periostin production in eosinophilic nasal polyps Dae Woo Kim, MD, PhD, Marianna.

Elina Jerschow, MD, MSc, Robert Y. Lin, MD, MSc, Moira M

Peter M. Wolfgram, MD, David B. Allen, MD

David D. Tieu, MD, Anju T. Peters, MD, Roderick T

Reply Journal of Allergy and Clinical Immunology

Possible role of TH17 cells in the pathogenesis of Stevens-Johnson syndrome and toxic epidermal necrolysis Yuichi Teraki, MD, Misaki Kawabe, MD, Seiichi.

Lower vitamin D status is closely correlated with eczema of the head and neck Seongmin Noh, MD, Chang Ook Park, MD, Jung Min Bae, MD, Jungsoo Lee, MD,

Microparticles in nasal lavage fluids in chronic rhinosinusitis: Potential biomarkers for diagnosis of aspirin-exacerbated respiratory disease Toru Takahashi,

A lower prevalence of asthma among patients with chronic rhinosinusitis in southern China Yunping Fan, MD, PhD, Shuli Chen, MD, PhD, Xiujuan Qu, MD,

Thymic stromal lymphopoietin activity is increased in nasal polyps of patients with chronic rhinosinusitis Deepti R. Nagarkar, PhD, Julie A. Poposki,

Expression of the cysteinyl leukotriene receptors cysLT1 and cysLT2 in aspirin-sensitive and aspirin-tolerant chronic rhinosinusitis Chris Corrigan,

Phillip Lieberman, MD, Michael Tankersley, MD

Increased expression of the epithelial anion transporter pendrin/SLC26A4 in nasal polyps of patients with chronic rhinosinusitis Sudarshan Seshadri,

Sudarshan Seshadri, PhD, Mariel Rosati, BS, David C

Chronic rhinosinusitis with nasal polyps is characterized by B-cell inflammation and EBV-induced protein 2 expression Kathryn E. Hulse, PhD, James E.

Phillip Lieberman, MD, David Golden, MD

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Increased noneosinophilic nasal polyps in chronic rhinosinusitis in US second- generation Asians suggest genetic regulation of eosinophilia Mahboobeh.

A cluster-randomized trial shows telephone peer coaching for parents reduces children's asthma morbidity Jane M. Garbutt, MB, ChB, Yan Yan, MD, PhD,

Glandular mast cells with distinct phenotype are highly elevated in chronic rhinosinusitis with nasal polyps Tetsuji Takabayashi, MD, Atsushi Kato, PhD,

Sharon Seth, MD, David A. Khan, MD

What is an “eosinophilic phenotype” of asthma?

Autophagy: Nobel Prize 2016 and allergy and asthma research

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Geographic variability in childhood asthma prevalence in Chicago

Mary F. Linehan, PhD, Timothy L. Frank, MD, Michelle L

Paul V. Licciardi, PhD, Anne Balloch, MSc, Fiona M

Biology of nasal polyposis

Efficacy of nasal mometasone for the treatment of chronic sinonasal disease in patients with inadequately controlled asthma Anne E. Dixon, MA, BM BCh,

IL-10, TGF-β, and glucocorticoid prevent the production of type 2 cytokines in human group 2 innate lymphoid cells Noriko Ogasawara, MD, PhD, Julie A.

Jessica H. Savage, MD, MHS, Elizabeth C. Matsui, MD, MHS, Robert A

Pınar Uysal, MD, Esben Eller, MSc, PhD, Charlotte G

Macrolide antibiotics and asthma treatment

Endotypes and phenotypes of chronic rhinosinusitis: A PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy.

Asthma: The past, future, environment, and costs

Inflammation-mediated upregulation of centrosomal protein 110, a negative modulator of ciliogenesis, in patients with chronic rhinosinusitis Yinyan Lai,

Asthma Control Test: Reliability, validity, and responsiveness in patients not previously followed by asthma specialists Michael Schatz, MD, MS, Christine.

The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy Jennifer M. Maloney, MD, Magnus Rudengren, BSc, Staffan.

Natural history of cow’s milk allergy

Presentation transcript:

Age-related differences in the pathogenesis of chronic rhinosinusitis Seong H. Cho, MD, Seung J. Hong, MD, PhD, Brian Han, BA, Sun H. Lee, PhD, Lydia Suh, BSc, James Norton, MSc, David Lin, BA, David B. Conley, MD, Rakesh Chandra, MD, Robert C. Kern, MD, Bruce K. Tan, MD, Atsushi Kato, PhD, Anju Peters, MD, Leslie C. Grammer, MD, Robert P. Schleimer, PhD Journal of Allergy and Clinical Immunology Volume 129, Issue 3, Pages 858-860.e2 (March 2012) DOI: 10.1016/j.jaci.2011.12.002 Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Age-related distribution of the ECP and HNE protein levels in nasal lavage fluids from normal subjects and from patients with CRS as determined by ELISA. A, In the CRSwNP subtype, ECP levels in elderly patients were significantly lower compared with those in nonelderly patients. B and C, There was a significant negative correlation between ECP levels and age in patients with CRSwNP, but not in patients with CRSsNP. D-F, The HNE levels from normal subjects and from patients with CRS were not different by age, and there was no correlation between HNE levels with aging. E, Elderly; NE, nonelderly. Journal of Allergy and Clinical Immunology 2012 129, 858-860.e2DOI: (10.1016/j.jaci.2011.12.002) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Age-related distribution of the human S100A8/A9 protein levels in nasal lavage fluids from normal subjects and from patients with CRS as determined by ELISA. A, In normal controls and patients with CRSsNP, S100A8/9 levels in elderly subjects were significantly lower compared with those in nonelderly subjects. B-D, Levels of S100A8/A9 were significantly diminished with increasing age in normal controls and patients with both subtypes of CRS. E, Elderly; NE, nonelderly. Journal of Allergy and Clinical Immunology 2012 129, 858-860.e2DOI: (10.1016/j.jaci.2011.12.002) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Age-related distribution of the ECP and HNE protein levels in nasal lavage fluids from normal subjects as determined by ELISA. There was no significant correlation between age and levels of ECP (A) or HNE (B). Journal of Allergy and Clinical Immunology 2012 129, 858-860.e2DOI: (10.1016/j.jaci.2011.12.002) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions