Liver fibrosis after CCl4 injury in 5αR1-KO and WT mice.

Slides:

Advertisements

Similar presentations

三重大学医学部病理 Deficiency of tenascin-C attenuates liver

Advertisements

Plasminogen Activator Inhibitor-1 Deficiency Prevents Hypertension and Vascular Fibrosis in Response to Long- term Nitric Oxide Synthase Inhibition by.

Mouse Carotid Artery Ligation Induces Platelet-Leukocyte–Dependent Luminal Fibrin, Required for Neointima Development by Tomihisa Kawasaki, Mieke Dewerchin,

Platelet TGF-β1 deficiency decreases liver fibrosis in a mouse model of liver injury by Shahrouz Ghafoory, Rohan Varshney, Tyler Robison, Karim Kouzbari,

Inhibition of ILK by QLT-0267 suppresses type I and type III collagen expression and ameliorates interstitial collagen deposition and renal fibrosis after.

AAV8‐hAAT‐FGF21 treatment improves liver fibrosis

PD-1 deficiency promotes the development of splenic GCs in male mice, and MR1 dissolves GCs in both genders. PD-1 deficiency promotes the development of.

Metabolic profile of Tfe3 KO mice

Fibroblast activation in WT and NFATc2-deficient mice.

Expression of IL-1α in goblet cells and their destruction during DSS-induced colitis. Expression of IL-1α in goblet cells and their destruction during.

INT-767 treatment prevents renal lipid accumulation in diabetic DBA/2J mice. INT-767 treatment prevents renal lipid accumulation in diabetic DBA/2J mice.

Fig. 1. NASH and fibrosis develop late in mice fed an HFD.

Stat3 promotes lung fibrosis and collagen synthesis independent of Smad3.A.Masson's trichrome stained sections of lung from gp130wt (wt), Smad3−/− (Smad3−/−),

TFE3 prevents diet‐induced obesity and metabolic syndrome

IFN-γ antagonizes TGF-β in vivo.

Romain Gallet et al. BTS 2016;1:14-28

IFN-γ activates the fibrinolytic system.

Type 1 immunity drives metabolic disease but protects against NAFLD

CD8α+ DC-deficient mice are highly susceptible to Lm infection in the absence of CD169+ macrophages. CD8α+ DC-deficient mice are highly susceptible to.

Modulation of Hepatic Fibrosis by c-Jun-N-Terminal Kinase Inhibition

NFATc2-deficient mice do not eliminate skin C. albicans infections.

The TGF-β pathway is activated in the skin after C

Cardiac Fibrosis at 18 Weeks Post TAC (A) Representative images (original magnification ×20) of Picrosirius red-stained cardiac tissue sections from HF +

Loss of DGKζ and Cbl-b results in a greater percentage of splenic CD8+ T cells with an activated phenotype. Loss of DGKζ and Cbl-b results in a greater.

Effect of plumbagin (PL) on the growth of prostate tumors in Pten-KO mice. Effect of plumbagin (PL) on the growth of prostate tumors in Pten-KO mice. A.

Fig. 4. Features of PH in LLC1 lung tumor mice.

Renal Fibrosis and Plasma Creatinine Levels at 18 Weeks Post TAC (A) Plasma creatinine levels. (B) Representative images (original magnification ×20) of.

Deficiency of TLR9 promotes more severe renal inflammation in imiquimod-induced autoimmunity. Deficiency of TLR9 promotes more severe renal inflammation.

ILK knockdown decreases mTOR signaling in PKD kidneys.

LXs reverse established DKD. (A) Study design overview.

IFN-γ antagonizes TGF-β in vivo.

Diabetic FXR KO kidney showed increased lipid accumulation.

A: Total collagen content by Sirius red staining in cardiac tissue of control (SD) animals. A: Total collagen content by Sirius red staining in cardiac.

BTG2 regulates gluconeogenic gene expression in diabetic mouse models

Streptozotocin treatment increased phospho–Thr231-tau immunoreactivity in mouse brain. Streptozotocin treatment increased phospho–Thr231-tau immunoreactivity.

Exogenous CRP administration causes fasting hyperglycemia and hyperinsulinemia without altering body composition. Exogenous CRP administration causes fasting.

Plaque area remained increased in the previously hyperglycemic mice.

TSG-6 suppressed APC activation in vitro and in vivo.

Sox4 promotes hepatic TG accumulation in vivo.

Glucose tolerance in WT and TRPM2-KO mice.

IFN-γ activates the fibrinolytic system.

ΑGLP-1R−/− mice show glucose intolerance and disturbed glucagon secretion in response to i.p. glucose administration. αGLP-1R−/− mice show glucose intolerance.

MiRNA expression profiling in adipocytes from wild-type (WT) and leptin-deficient ob/ob mice. miRNA expression profiling in adipocytes from wild-type (WT)

Knockout of SIRT1 in podocytes aggravates proteinuria and kidney injury in db/db mice. Knockout of SIRT1 in podocytes aggravates proteinuria and kidney.

Higher levels of PEDF-impaired skin structure and function.

Reduced OXPHOS expression and increased UCP expression.

Innate immune and fibrinolytic systems cooperate also during bacterial infections. Innate immune and fibrinolytic systems cooperate also during bacterial.

Hepatic fuel metabolism in male 5αR1-KO and WT mice

Insulin resistance and hepatic steatosis in ASKO mice.

PEDF inhibits Wnt/T-cell factor/β-catenin signaling in resting and wounded skin. PEDF inhibits Wnt/T-cell factor/β-catenin signaling in resting and wounded.

Urinary albumin excretion and histology of glomeruli.

Glucose-stimulated insulin secretion, plasma glucagon levels, and pancreatic hormone contents. Glucose-stimulated insulin secretion, plasma glucagon levels,

Comparison of the percentages of ducts in the pancreas containing cells showing positive staining for the different markers between control hamster Ig–and.

Expression of PKCδ in islets and other tissues of control and PKCδKN-overexpressing mice. Expression of PKCδ in islets and other tissues of control and.

GTTs and ITTs. A: GTTs of WT (◇), LepTg (♦), Akita (open circles), and LepTg:Akita (closed circles) mice at 8 and 16 weeks of age. GTTs and ITTs. A: GTTs.

Histologic features of brain vessels in patient 7 with MNGIE

PTZ-induced c-Fos and Arc proteins in hippocampal dentate gyrus

A: Representative sections from the LV of sham and diabetic Ntg and IGF-1R mice. A: Representative sections from the LV of sham and diabetic Ntg and IGF-1R.

Proprioceptive sensory neurons and muscle spindles are marked reduced in adult Swl/+ mice. Proprioceptive sensory neurons and muscle spindles are marked.

In vivo thrombosis of tumor vasculature.

Chronic Treg reduction results in dermal fibrosis.

PI3Kγ promotes macrophage PDGF-BB expression to control PDAC fibrosis.

N1 decoys reduced perfusion and JAG-specific decoys disrupted pericyte association in Mm5MT-FGF4 tumors. N1 decoys reduced perfusion and JAG-specific decoys.

Cabozantinib causes significant tumor cell elimination in vivo, but modest apoptosis induction in vitro. Cabozantinib causes significant tumor cell elimination.

Fibroblast activation in WT and NFATc2-deficient mice.

Fig. 2. Col IV–Ac2-26 NPs increase subendothelial collagen in Ldlr−/− mice with established atherosclerosis. Col IV–Ac2-26 NPs increase subendothelial.

Detection of microcalcifications in 4T1 mammary tumors and human breast tumor tissue. Detection of microcalcifications in 4T1 mammary tumors and human.

Administration of anti-glial cell line-derived neurotrophic factor (anti-GDNF) antibodies reduces liver fibrosis development in mice. Administration of.

Glial cell line-derived neurotrophic factor (GDNF) is upregulated in mouse liver fibrosis. Glial cell line-derived neurotrophic factor (GDNF) is upregulated.

Greater influx of PMNs and ST using PEGPH20/shIDO-ST.

Presentation transcript:

Liver fibrosis after CCl4 injury in 5αR1-KO and WT mice. Liver fibrosis after CCl4 injury in 5αR1-KO and WT mice. Representative images of liver sections (5 µm) stained with picrosirius red to show collagen deposition. Collagen is not detected in WT mice (A) or KO mice (B) receiving injections of vehicle. Mice deficient in 5αR1 have greater induction of collagen after CCl4 administration, including evidence of bridging fibrosis (KO) (D), compared with WT controls (C). Dawn E.W. Livingstone et al. Diabetes 2015;64:447-458 ©2015 by American Diabetes Association