Examples of antibiotic hybrid drugs that are active against Gram-negative pathogens: trimethoprim linked to ciprofloxacin–BP-4Q-002 (hybrid 5), the TyrRS.

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Examples of antibiotic hybrid drugs that are active against Gram-negative pathogens: trimethoprim linked to ciprofloxacin–BP-4Q-002 (hybrid 5), the TyrRS inhibitor 3-(2-fluorophenyl)furan-2(5H)-one linked to ciprofloxacin (hybrid 6), the flavonoid naringenin linked to ciprofloxacin (hybrid 7), neomycin B linked to ciprofloxacin via an aromatic triazole linker (hybrid 8), and neomycin B linked to ciprofloxacin with a hydroxyl group-containing aliphatic triazole linker (hybrid 9). Examples of antibiotic hybrid drugs that are active against Gram-negative pathogens: trimethoprim linked to ciprofloxacin–BP-4Q-002 (hybrid 5), the TyrRS inhibitor 3-(2-fluorophenyl)furan-2(5H)-one linked to ciprofloxacin (hybrid 6), the flavonoid naringenin linked to ciprofloxacin (hybrid 7), neomycin B linked to ciprofloxacin via an aromatic triazole linker (hybrid 8), and neomycin B linked to ciprofloxacin with a hydroxyl group-containing aliphatic triazole linker (hybrid 9). Most antibiotic hybrid drugs consist of a fluoroquinolone. Ronald Domalaon et al. Clin. Microbiol. Rev. 2018; doi:10.1128/CMR.00077-17