Hongcan Shi, MD, PhD, Hong Xu, MD, Dan Lu, MD, Jun Wu, MD

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Presentation transcript:

Animal models of tracheal allotransplantation using vitrified cryopreservation Hongcan Shi, MD, PhD, Hong Xu, MD, Dan Lu, MD, Jun Wu, MD The Journal of Thoracic and Cardiovascular Surgery Volume 138, Issue 5, Pages 1222-1226 (November 2009) DOI: 10.1016/j.jtcvs.2009.05.028 Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Animal model of tracheal orthotopic transplantation. The Journal of Thoracic and Cardiovascular Surgery 2009 138, 1222-1226DOI: (10.1016/j.jtcvs.2009.05.028) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Pathologic characteristics of group A on day 28 after cryopreserved allotransplantation. Tracheal cartilaginous structure was intact (black arrow), with no obvious lymphocytes infiltration. Many ink-perfused small vessels were found (blank arrow) (original magnification, ×200). The Journal of Thoracic and Cardiovascular Surgery 2009 138, 1222-1226DOI: (10.1016/j.jtcvs.2009.05.028) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Pathologic characteristics after tracheal autotransplantation showed that the cartilaginous plates were well retained (black arrow). Ink-perfused small vessels were also found (blank arrow). From a rabbit in group B on day 28 after surgery (original magnification, ×200). The Journal of Thoracic and Cardiovascular Surgery 2009 138, 1222-1226DOI: (10.1016/j.jtcvs.2009.05.028) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 In one of the specimens from group C on day 8, substantial monocytes and lymphocytes infiltration were observed in the submucosa and surrounding vessels, but no obvious ink-perfused vessels were observed. Local necrosis or disintegration of cartilaginous plates occurred (black arrow). No noticeable ink-perfused vessels were found (original magnification, ×200). The Journal of Thoracic and Cardiovascular Surgery 2009 138, 1222-1226DOI: (10.1016/j.jtcvs.2009.05.028) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions