Randomized trial to evaluate azithromycin's effects on serum and upper airway IL-8 levels and recurrent wheezing in infants with respiratory syncytial.

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Presentation transcript:

Randomized trial to evaluate azithromycin's effects on serum and upper airway IL-8 levels and recurrent wheezing in infants with respiratory syncytial virus bronchiolitis Avraham Beigelman, MD, MSCI, Megan Isaacson-Schmid, BSc, Geneline Sajol, BSc, Jack Baty, BA, Oscar M. Rodriguez, MD, Erin Leege, MPH, Kevin Lyons, BSc, Toni L. Schweiger, RN, Jie Zheng, MA, Kenneth B. Schechtman, PhD, Mario Castro, MD, MPH, Leonard B. Bacharier, MD Journal of Allergy and Clinical Immunology Volume 135, Issue 5, Pages 1171-1178.e1 (May 2015) DOI: 10.1016/j.jaci.2014.10.001 Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Participant flow of the APW-RSV trial. aSome patients were excluded based on having more than 1 exclusion criterion. Details for those screened but not eligible were not collected. bOne of the patients who was lost to follow-up had 11 (of 12) months of follow-up and contributed all biological samples for cytokine measurements. Dx, Diagnosis. Journal of Allergy and Clinical Immunology 2015 135, 1171-1178.e1DOI: (10.1016/j.jaci.2014.10.001) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 APW-RSV Study design. FU, Follow-up; Hx/PE, history/physical examination; Sx, symptom. Journal of Allergy and Clinical Immunology 2015 135, 1171-1178.e1DOI: (10.1016/j.jaci.2014.10.001) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Mean serum IL-8 levels (on a logarithmic scale) between randomization and day 8. P = .62, change in serum IL-8 concentration measured between randomization and day 8 compared between the treatment groups. Journal of Allergy and Clinical Immunology 2015 135, 1171-1178.e1DOI: (10.1016/j.jaci.2014.10.001) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Mean nasal lavage IL-8 levels (on a logarithmic scale) over the treatment period. *P = .03, change in nasal lavage IL-8 concentration measured between randomization and day 15 compared between treatment groups. Journal of Allergy and Clinical Immunology 2015 135, 1171-1178.e1DOI: (10.1016/j.jaci.2014.10.001) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 5 Probability of not having at least 3 episodes of wheezing. Journal of Allergy and Clinical Immunology 2015 135, 1171-1178.e1DOI: (10.1016/j.jaci.2014.10.001) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions