C/EBPα induces HSD1 expression and is a substrate of USP2–45.

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Presentation transcript:

C/EBPα induces HSD1 expression and is a substrate of USP2–45. C/EBPα induces HSD1 expression and is a substrate of USP2–45. A and B: Induction of HSD1 mRNA (A) and protein (B) expression by C/EBPα in primary hepatocytes. *P < 0.01, C/EBPα vs. GFP. C: Deubiquitination of C/EBPα by USP2–45 in transiently transfected 293 cells. D: Model depicting the role of USP2–45 in mediating circadian and nutritional regulation of hepatic gluconeogenesis and glucose secretion. Matthew M. Molusky et al. Diabetes 2012;61:1025-1035 ©2012 by American Diabetes Association