Insulin resistance and hepatic steatosis in ASKO mice.

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Insulin resistance and hepatic steatosis in ASKO mice. Insulin resistance and hepatic steatosis in ASKO mice. Glucose tolerance (A) and plasma insulin concentrations (B) during the glucose tolerance tests (GTT) and insulin tolerance tests (ITT) (C) in 3-, 6-, and 10-month-old WT and ASKO mice. M, month. Values are the mean ± SEM (n = 6). Representative Western blot images (left) for the indicated proteins in Epi-WAT (D) and liver (E) and the quantification (right) by densitometry of phosphorylated AKT (P-AKT) normalized to total AKT for 3-, 6-, and 10-month-old WT and ASKO mice. Values are the mean ± SEM, n = 4. F: Weight changes of the liver in 3-, 6-, and 10-month-old WT and ASKO mice. Liver weight is normalized to body weight. Values are the mean ± SEM (n = 9). G: Oil Red O staining of the liver from 3-, 6-, and 10-month-old WT and ASKO mice. Nuclei are counterstained with hematoxylin. The red-colored droplets represent the LD. Scale bar is 50 μm. H: Liver TAG contents from 3-, 6-, and 10-month-old WT and ASKO mice. TAG content is normalized to liver weight. Values are the mean ± SEM, n = 4–5. *P < 0.05, **P < 0.01, ***P < 0.001 for ASKO vs. WT. Lu Liu et al. Diabetes 2014;63:2320-2331 ©2014 by American Diabetes Association