Effect of age on the clinical profile and systemic absorption and disposition of levobupivacaine after epidural administration Simon M.J.G. , Veering.

Slides:

Advertisements

Similar presentations

S. Arenas-Lopez, H. Mulla, S. Manna, A. Durward, I. A. Murdoch, S. M

Advertisements

Preventing surgical deaths: critical care and intensive care outreach services in the postoperative period D.R. Goldhill British Journal of Anaesthesia

M. Kokki, P. Välitalo, M. Kuusisto, V. P. Ranta, K. Raatikainen, H

When fasted is not empty: a retrospective cohort study of gastric content in fasted surgical patients† P Van de Putte, L Vernieuwe, A Jerjir, L Verschueren,

Predictive performance of eleven pharmacokinetic models for propofol infusion in children for long-duration anaesthesia M Hara, K Masui, D.J. Eleveld,

Pharmacokinetic profile of epidurally administered methylnaltrexone, a novel peripheral opioid antagonist in a rabbit model D.B. Murphy, H. El Behiery,

Why is the surgical high-risk patient still at risk?

C.-A. Ewaldsson, R.G. Hahn British Journal of Anaesthesia

Supplemental oxygen and surgical site infection: getting to the truth

Type of anaesthesia and patient quality of recovery: a randomized trial comparing propofol–remifentanil total i.v. anaesthesia with desflurane anaesthesia

Comparison of the effects of thoracic epidural analgesia and i. v

G Turner, M.J. Goldacre, T Lambert, J.W. Sear

A.R. Absalom, V. Mani, T. De Smet, M.M.R. F. Struys

Prediction of tracheostomy tube size for paediatric long-term ventilation: an audit of children with spinal cord injury Behl S. , Watt J.W.H. British.

Pharmacokinetics of ropivacaine in patients with chronic renal failure

Spinal cord stimulation in complex regional pain syndrome: cervical and lumbar devices are comparably effective Forouzanfar T , Kemler M.A. , Weber W.E.J.

Delayed retroperitoneal haematoma after failed lumbar plexus block

Determination of the EC50 of levobupivacaine for femoral and sciatic perineural infusion after total knee arthroplasty G.A. McLeod, J. Dale, D. Robinson,

Volume kinetics of glucose 2

Barriers to clinical research in Africa: a quantitative and qualitative survey of clinical researchers in 27 African countries A. Conradie, R. Duys,

Epidural infusion or combined femoral and sciatic nerve blocks as perioperative analgesia for knee arthroplasty† Davies A.F. , Segar E.P. , Murdoch J.

Predictive performance of computer-controlled infusion of remifentanil during propofol/remifentanil anaesthesia M.J. Mertens, F.H.M. Engbers, A.G.L.

H. Yamauchi, S. Ito, H. Sasano, T. Azami, J. Fisher, K. Sobue

A. A. Klein, T. Collier, J. Yeates, L. F. Miles, S. N. Fletcher, C

Death and its diagnosis by doctors

Population pharmacokinetics of nalbuphine after surgery in children

Efficacy of intravenous magnesium in neuropathic pain

J.B. Whiteside, D Burke, J.A.W. Wildsmith

Awareness and the EEG power spectrum: analysis of frequencies

Faster wash-out and recovery for desflurane vs sevoflurane in morbidly obese patients when no premedication is used L. La Colla, A. Albertin, G. La Colla,

Population pharmacokinetics of the two enantiomers of tramadol and O-demethyl tramadol after surgery in children F. Bressolle, A. Rochette, S. Khier,

T. Iirola, S. Vilo, R. Aantaa, M. Wendelin-Saarenhovi, P. J

I.V. paracetamol as an adjunct to patient-controlled epidural analgesia with levobupivacaine and fentanyl in labour: a randomized controlled study K.

Regional and temporal changes in cardiovascular responses to norepinephrine and vasopressin during continuous infusion of lipopolysaccharide in conscious.

Age- and therapy-related effects on morphine requirements and plasma concentrations of morphine and its metabolites in postoperative infants N.J. Bouwmeester,

Population pharmacokinetics of epsilon-aminocaproic acid in infants undergoing craniofacial reconstruction surgery P.A. Stricker, A.F. Zuppa, J.E. Fiadjoe,

Changes in serum albumin concentration and volume expanding effects following a bolus of albumin 20% in septic patients Margarson M.P. , Soni N.C.

Double-blind, randomized, placebo-controlled trial comparing rofecoxib with dexketoprofen trometamol in surgical dentistry Jackson I.D. , Heidemann B.H.

Prevalence of postoperative bladder distension and urinary retention detected by ultrasound measurement Lamonerie L , Marret E , Deleuze A , Lembert.

Pharmacogenetics of codeine metabolism in an urban population of children and its implications for analgesic reliability D.G. Williams, A. Patel, R.F.

Anaesthesia for awake craniotomy—evolution of a technique that facilitates awake neurological testing A. Sarang, J. Dinsmore British Journal of Anaesthesia

Sugammadex rapidly reverses moderate rocuronium- or vecuronium-induced neuromuscular block during sevoflurane anaesthesia: a dose–response relationship

Pharmacokinetics of remifentanil and its major metabolite, remifentanil acid, in ICU patients with renal impairment† Pitsiu M , Wilmer A , Bodenham A.

Comparison of 1% and 2% lidocaine epidural anaesthesia combined with sevoflurane general anaesthesia utilizing a constant bispectral index A Shono, S.

Effect of epinephrine on epidural, intrathecal, and plasma pharmacokinetics of ropivacaine and bupivacaine in sheep M. Ratajczak-Enselme, J.-P. Estebe,

Interstitial muscle concentrations of rocuronium under steady-state conditions in anaesthetized dogs: actual versus predicted values Ezzine S. , Varin.

Effectiveness of continuous wound infusion of 0

GlideScope® video laryngoscope: a randomized clinical trial in 203 paediatric patients† J.-T. Kim, H.-S. Na, J.-Y. Bae, D.-W. Kim, H.-S. Kim, C.S. Kim,

Tissue oxygen tension (PTO2) in anaesthesia and perioperative medicine

Pharmacokinetics of intravenous dexmedetomidine in children under 11 yr of age S. Vilo, P. Rautiainen, K. Kaisti, R. Aantaa, M. Scheinin, T. Manner, K.T.

T.G. Hansen, K.F. Ilett, S.I. Lim, C. Reid, L.P. Hackett, R. Bergesio

Comparative total and unbound pharmacokinetics of cefazolin administered by bolus versus continuous infusion in patients undergoing major surgery: a randomized.

Effects of pre-eclampsia on maternal plasma, cerebrospinal fluid, and umbilical cord urotensin II concentrations: a pilot study† E. Cowley, J.P. Thompson,

Does hyperbaric oxygen have positive effect on neurological recovery in spinal–epidural haematoma?: a case report Z. Wajima, S. Aida British Journal.

Editorial II: Solid as a ROC

Diffusion of nitrous oxide into the pleural cavity†

Development and validation of a preoperative scoring system to predict 30 day mortality in patients undergoing hip fracture surgery M.J. Maxwell, C.G.

High-fidelity patient simulation: validation of performance checklists

Rocuronium plasma concentrations during three phases of liver transplantation: relationship with early postoperative graft liver function†‡ L. Gao, I.

Haemodynamic effects of oxytocin given as i. v

Population pharmacokinetic analysis of ropivacaine and its metabolite 2′,6′- pipecoloxylidide from pooled data in neonates, infants, and children L. Aarons,

I.V. ropivacaine compared with lidocaine for the treatment of tinnitus

Unconscious learning during surgery with propofol anaesthesia†

Wee L. , Barron J. , Toye R. British Journal of Anaesthesia

Plasma lidocaine concentrations following insertion of 2% lidocaine gel into the uterine cavity after uterine balloon thermal ablation G.F. Rousseau,

Volume kinetics of glucose 2

N Schütz, F Peták, C Barazzone-Argiroffo, F Fontao, W Habre

K. Holte, N.E. Sharrock, H. Kehlet British Journal of Anaesthesia

High plasma ropivacaine concentrations after fascia iliaca compartment block in children Paut O , Schreiber E , Lacroix F , Meyrieux V , Simon N , Lavrut.

R. Parke, S. McGuinness, R. Dixon, A. Jull

Presentation transcript:

Effect of age on the clinical profile and systemic absorption and disposition of levobupivacaine after epidural administration Simon M.J.G. , Veering B.T. , Stienstra R. , van Kleef J.W. , Burm A.G.L. British Journal of Anaesthesia Volume 93, Issue 4, Pages 512-520 (October 2004) DOI: 10.1093/bja/aeh241 Copyright © 2004 British Journal of Anaesthesia Terms and Conditions

Fig 1 Mean and individual values for the upper level of anaesthesia during epidural anaesthesia with levobupivacaine 0.75% for the three age groups (Group 1, 18–44 yr; Group 2, 45–70 yr; Group 3, >70 yr). Data are averages of the levels measured on the right and left side of the trunk. British Journal of Anaesthesia 2004 93, 512-520DOI: (10.1093/bja/aeh241) Copyright © 2004 British Journal of Anaesthesia Terms and Conditions

Fig 2 Plasma concentrations after (a) i.v. infusion of D3-levobupivacaine and (b) epidural administration of levobupivacaine in individual subjects. British Journal of Anaesthesia 2004 93, 512-520DOI: (10.1093/bja/aeh241) Copyright © 2004 British Journal of Anaesthesia Terms and Conditions

Fig 3 Cumulative fractions absorbed of levobupivacaine vs time in individual surgical patients. Absorption–time data were obtained by deconvolution of the measured concentrations unlabelled levobupivacaine concentration–time data against the i.v. unit impulse–response curve, derived from the D3-levobupivacaine concentration–time data. British Journal of Anaesthesia 2004 93, 512-520DOI: (10.1093/bja/aeh241) Copyright © 2004 British Journal of Anaesthesia Terms and Conditions

Fig 4 Graphical representation of the relationship between the peak plasma concentrations (Cmax) and the fractions absorbed during the initial absorption phase (F1) for the youngest, middle, and oldest age group of patients. In the entire study population, a larger F1 was associated with a higher Cmax. British Journal of Anaesthesia 2004 93, 512-520DOI: (10.1093/bja/aeh241) Copyright © 2004 British Journal of Anaesthesia Terms and Conditions