Acute onset/flares of dermatomyositis following ingestion of IsaLean herbal supplement: Clinical and immunostimulatory findings Majid Zeidi, MD, Peter.

Slides:

Advertisements

Similar presentations

Topically applied ascorbic acid solution for the treatment of basal cell carcinoma (BCC) Péter Holló, MD, PhD, Hajnalka Jókai, MD, PhD, Judit Hársing,

Advertisements

Steven Q. Wang, MD, Leonard H. Goldberg, MD, FRCP

Cutaneous polyarteritis nodosa presenting as a solitary blue toe

Comparison of histopathologic–clinical characteristics of Jessner's lymphocytic infiltration of the skin and lupus erythematosus tumidus: Multicenter.

Ghina Ghazeeri, MD, Ossama Abbas, MD

Cutaneous vasculitis in two patients taking an herbal supplement containing black cohosh Adam Ingraffea, BA, Kevin Donohue, MD, Caroline Wilkel, MD,

Accuracy of biopsy sampling for subtyping basal cell carcinoma

Relationship among human herpesvirus 6 reactivation, serum interleukin 10 levels, and rash/graft-versus-host disease after allogeneic stem cell transplantation

Fluoroscopy-induced chronic radiation dermatitis (FICRD) after endovascular abdominal aortic aneurysm endoleak repair Alexis B. Lyons, MS, Valerie M.

Seven cases of complete and incomplete forms of Churg-Strauss syndrome not related to leukotriene receptor antagonists Androniki Bili, MD, John J. Condemi,

Aggressive cutaneous infection with Mycobacterium marinum in two patients receiving anti–tumor necrosis factor-alfa agents Julie Caron, MD, Carine Michot,

Toxic epidermal necrolysis in the absence of circulating T cells: A possible role for resident memory T cells Hisato Iriki, MD, Takeya Adachi, MD, Mariko.

Idiopathic eruptive macular pigmentation associated with pregnancy and Hashimoto thyroiditis Danica Milobratovic, MD, Sanja Djordjevic, MD, Jelica Vukicevic,

Quinacrine Suppresses Tumor Necrosis Factor-α and IFN-α in Dermatomyositis and Cutaneous Lupus Erythematosus Paul Alves, Muhammad M. Bashir, Maria Wysocka,

Jacqueline J. Russo, MD, Keira L. Barr, MD, Larissa Z

Secondary syphilis presenting as scrotal eczema

Iatrogenic hyperpigmentation in chronically infected hepatitis C patients treated with pegylated interferon and ribavirin Jennifer Lin, MD, Jason P.

Peter C. Schalock, MD, Jeoffrey B. Brennick, MD, James G. H

Photo-induced Stevens-Johnson syndrome

Rapid deterioration in a patient with primary aggressive cutaneous epidermotropic CD8+ cytotoxic T-cell (‘Berti’) lymphoma after administration of adalimumab

Squamous cell carcinoma tumor thrombus encountered during Mohs micrographic surgery Gary Mendese, MD, Jeremy Bordeaux, MD, MPH, Sean Pattee, MD, Mary.

2 Lt Dane Dicaro, BS, Capt Casey Bowen, MD, LTC Scott R. Dalton, DO

Tuberculous cellulitis as a manifestation of miliary tuberculosis in a patient with malignancy-associated dermatomyositis Ji Eun Kim, MD, Joo Yeon Ko,

Clinicopathologic features and T-cell receptor gene rearrangement findings of mycosis fungoides palmaris et plantaris Sang-Tae Kim, MD, Young-Seung Jeon,

Atypical lymphocytic reaction with epidermotropism and lymphocytic vasculopathic reaction (lymphocytic vasculitis) after treatment with imiquimod Jesús.

Development of a reticular rash in a febrile woman: An unusual cutaneous presentation of angioimmunoblastic T-cell lymphoma Michelle S. Min, MSci, Jonathan.

Photo-induced erythema multiforme associated with vandetanib administration Dolores Caro-Gutiérrez, MD, Maria Uxúa Floristán Muruzábal, MD, Enrique Gómez.

Rachel L. Kyllo, BS, Mary Kendall Parker, MD, Ilana Rosman, MD, Amy C

Volume 1, Issue 1, Pages 9-11 (January 2015)

A definitive case of metastatic folliculotropic melanoma

Catherine A. Necessary, BA, David Roffwarg, MD, Darrel Ellis, MD

Lichen striatus associated with etanercept treatment of rheumatoid arthritis Viviana Lora, MD, Jean Kanitakis, MD, Alessandra Latini, MD, Carlo Cota,

Digital metastasis of tongue squamous cell carcinoma

Amyopathic dermatomyositis presenting during pregnancy

Myiasis in a giant squamous cell carcinoma

Donna M. Hepper, MD, Peggy Wu, MD, Milan J. Anadkat, MD

Solitary mastocytoma in an adult with an unusual clinical presentation

Volume 3, Issue 4, Pages (July 2017)

Standard step sectioning of skin biopsy specimens diagnosed as superficial basal cell carcinoma frequently yields deeper and more aggressive subtypes

Bullous rheumatoid neutrophilic dermatosis

Volume 4, Issue 5, Pages (June 2018)

Romidepsin-induced neutrophilic urticaria

A case of adult T-cell leukemia/lymphoma in the Midwest

Treatment of anal intraepithelial neoplasia in patients with acquired HIV with imiquimod 5% cream* Alexander Kreuter, MD, Bettina Hochdorfer, MD, Markus.

Warren L. Macaulay (1915–2006) Walter Burgdorf, MD, Werner Kempf, MD

Keratosis follicularis spinulosa decalvans in a family

Leflunomide as adjuvant treatment of dermatomyositis

Erythema dyschromicum perstans showing resolution in an adult

Spectrum and progression of disease from condyloma to aggressive anogenital squamous cell carcinoma in 3 HIV-positive patients Olaf Rodriguez, BS, Carrie.

Cannabinoid Reduces Inflammatory Cytokines, Tumor Necrosis Factor-α, and Type I Interferons in Dermatomyositis In Vitro Elizabeth S. Robinson, Paul Alves,

Grace A. Hile, BS, Lori Lowe, MD, J. Michelle Kahlenberg, MD, PhD

Acute graft-versus-host disease arising within tattooed skin

Treatment of shiitake dermatitis by balneo PUVA therapy

Early B-cell chronic lymphocytic leukemia presenting as cutaneous lesions with a normal peripheral blood lymphocyte count Simon D.J. Gibbs, MBBS, David.

Hemorrhagic bullous dermatosis caused by warfarin therapy

Subcutaneous sarcoidosis presenting after treatment of Cushing's disease Jill C. Fichtel, MD, Anna Kay Wiggins Duckworth, MD, Temitope Soares, PharmD,

A randomized controlled study of low-dose UVA1, medium-dose UVA1, and narrowband UVB phototherapy in the treatment of localized scleroderma Alexander.

Jose Fernández-Vozmediano, PhD, Jose Armario-Hita, MD

Clinicopathologic lessons in distinguishing cicatricial alopecia: 7 Cases of lichen planopilaris misdiagnosed as discoid lupus Vinod E. Nambudiri, MD,

Dermatomyositis associated with malignant melanoma—A marker of poor prognosis? Meinhard Schiller, MD, Markus Böhm, MD, Peter Hensen, MD, Helge Riemann,

Treatment of cutaneous pseudolymphoma with interferon alfa-2b

Atypical Mycobacterium furunculosis occurring after pedicures

Marked and restricted cutaneous pigmentation induced by selective intra-arterial cisplatin infusion Teruki Yanagi, MD, Masashi Akiyama, MD, PhD, Satoru.

Vesiculopustules in adult-onset Still's disease

Michael Conroy, MD, MS, Lindsay Sewell, MD, O

Acanthosis nigricans in a patient with sarcoma of unknown origin

Grace A. Hile, BS, Lori Lowe, MD, J. Michelle Kahlenberg, MD, PhD

Topically applied ascorbic acid solution for the treatment of basal cell carcinoma (BCC) Péter Holló, MD, PhD, Hajnalka Jókai, MD, PhD, Judit Hársing,

Cutaneous polyarteritis nodosa presenting as a solitary blue toe

Atypical pemphigus involving the esophagus with IgG antibodies to desmoglein 3 and IgA antibodies to desmoglein 1 Shigeki Inui, MD, PhD, Masayuki Amagai,

Presentation transcript:

Acute onset/flares of dermatomyositis following ingestion of IsaLean herbal supplement: Clinical and immunostimulatory findings Majid Zeidi, MD, Peter B. Chansky, MD, Victoria P. Werth, MD Journal of the American Academy of Dermatology Volume 80, Issue 3, Pages 801-804 (March 2019) DOI: 10.1016/j.jaad.2018.08.019 Copyright © 2018 Terms and Conditions

Fig 1 Photograph of patient 1 showing facial erythema, heliotrope rash, and V sign. Skin biopsy specimen of patient 1 (hematoxylin-eosin stain; original magnification: ×20) showing subtle vacuolar changes within the basal keratinocytes, dilated blood vessels, and sparse superficial lymphocytic infiltrates. Photograph of patient 2 showing the Gottron sign on the dorsal aspect of the hands. Skin biopsy specimen of patient 2 (hematoxylin-eosin stain; original magnification: ×20) with dermatomyositis showing interface dermatitis with vacuolization of basal keratinocytes, dilated blood vessels, and sparse superficial lymphocytic infiltrates (poikilodermatous changes); a thickened basement membrane is seen in the insert (periodic acid–Schiff stain; original magnification: ×40). Journal of the American Academy of Dermatology 2019 80, 801-804DOI: (10.1016/j.jaad.2018.08.019) Copyright © 2018 Terms and Conditions

Fig 2 Secretion of tumor necrosis factor-α (TNF-α), interferon-α (IFN-α), and interferon beta (IFN-β) from unstimulated peripheral blood mononuclear cells (PBMCs) of patients with dermatomyositis and from PBMCs of the same patients that have been stimulated with different concentrations of IsaLean. Effects of anti–Toll-like receptor (TLR4) antibody versus sham on secretion of TNF-α from the unstimulated and lipopolysaccharide (LPS)- and IsaLean-stimulated PBMCs of patients with dermatomyositis. Effects of quinacrine (QC) and hydroxychloroquine (HCQ) versus sham on secretion of TNF-α from the unstimulated and IsaLean-stimulated PBMCs of patients with dermatomyositis (n = 5). ns, Not significant. Journal of the American Academy of Dermatology 2019 80, 801-804DOI: (10.1016/j.jaad.2018.08.019) Copyright © 2018 Terms and Conditions