The natural history of egg allergy in an observational cohort

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The natural history of egg allergy in an observational cohort Scott H. Sicherer, MD, Robert A. Wood, MD, Brian P. Vickery, MD, Stacie M. Jones, MD, Andrew H. Liu, MD, David M. Fleischer, MD, Peter Dawson, PhD, Lloyd Mayer, MD, A. Wesley Burks, MD, Alexander Grishin, PhD, Donald Stablein, PhD, Hugh A. Sampson, MD Journal of Allergy and Clinical Immunology Volume 133, Issue 2, Pages 492-499.e8 (February 2014) DOI: 10.1016/j.jaci.2013.12.1041 Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Kaplan-Meier analysis of egg allergy resolution over time with pointwise 95% CIs. Journal of Allergy and Clinical Immunology 2014 133, 492-499.e8DOI: (10.1016/j.jaci.2013.12.1041) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Kaplan-Meier analysis representing the relationship of egg allergy resolution to baseline egg-specific IgE levels. Individual curves represent IgE levels of less than 2 kUA/L (blue), 2 to 10 kUA/L (red), and 10 kUA/L or greater (green). Journal of Allergy and Clinical Immunology 2014 133, 492-499.e8DOI: (10.1016/j.jaci.2013.12.1041) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Kaplan-Meier analysis representing the relationship of egg allergy resolution to clinical presentation of initial reactions to egg. The mutually exclusive clinical presentation of the initial reaction to egg ingestion was categorized as the following: AD diagnosis (flare of AD; this category included egg-specific IgE >2 kUA/L), skin-only reactions (acute hives and/or angioedema), or systemic reactions (eg, more than isolated skin, including respiratory and gastrointestinal reactions). Journal of Allergy and Clinical Immunology 2014 133, 492-499.e8DOI: (10.1016/j.jaci.2013.12.1041) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Kaplan-Meier Analysis representing the relationship of egg allergy resolution to baseline AD. Individual curves represent no/mild AD (blue) and moderate/severe AD (red). Journal of Allergy and Clinical Immunology 2014 133, 492-499.e8DOI: (10.1016/j.jaci.2013.12.1041) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Kaplan-Meier analysis representing the relationship of egg allergy resolution to baseline egg SPT wheal size. Individual curves represent wheal sizes of less than 5 mm (blue) or greater than 5 mm (red). Journal of Allergy and Clinical Immunology 2014 133, 492-499.e8DOI: (10.1016/j.jaci.2013.12.1041) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Kaplan-Meier analysis representing the relationship of egg allergy resolution to baseline egg-specific IgG4 levels. Individual curves represent IgG4 levels of less than 0.10 mgA/L (blue), 0.10 to 0.40 mgA/L (red), and 0.40 mgA/L or greater (green). Journal of Allergy and Clinical Immunology 2014 133, 492-499.e8DOI: (10.1016/j.jaci.2013.12.1041) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E4 Kaplan-Meier analysis representing the relationship of egg-stimulated IL-4 expression based on observed tertiles of response (high in red, medium in blue, and low in green). Journal of Allergy and Clinical Immunology 2014 133, 492-499.e8DOI: (10.1016/j.jaci.2013.12.1041) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E5 This figure represents results of a composite index based on the baseline egg-specific IgE level and clinical presentation of egg allergy being limited to the skin or including symptoms beyond the skin (see text). Five examples representing common clinical presentations are shown, illustrating systemic reactions with egg-specific IgE levels of 15 kUA/L (brown line) and 5 kUA/L (purple), skin-limited reactions with egg-specific IgE levels of 10 kUA/L (green) and 0.5 kUA/L (blue), and AD with egg-specific IgE levels of 10 kUA/L (red). Journal of Allergy and Clinical Immunology 2014 133, 492-499.e8DOI: (10.1016/j.jaci.2013.12.1041) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions