Systemic treatment with AMPK activators decreases TRPA1 associated with membrane in DRG neurons of db/db mice. Systemic treatment with AMPK activators.

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Systemic treatment with AMPK activators decreases TRPA1 associated with membrane in DRG neurons of db/db mice. Systemic treatment with AMPK activators decreases TRPA1 associated with membrane in DRG neurons of db/db mice. Metformin (Met; 250 mg/kg) or AICAR (250 mg/kg) was intraperitoneally injected daily in db/db mice from postnatal week 5. Saline was used as the vehicle (veh). Mouse DRGs were collected 3 h after intraperitoneal injection for Western blot analysis. DRGs from 7-week-old db/db and m/m mice were used for total or membrane protein extraction; β-actin or N-cadherin was used to normalize the total or membrane TRPA1 protein level in neurons, respectively. Immunoblots (top) showing membrane TRPA1 (mTRPA1; A) and total TRPA1 (tTRPA1; B) in m/m and db/db mice. The scatter plots (bottom) show the normalized expression of mTRPA1 (A) and tTRPA1 (B) (n = 5 to 6, mean ± SD). **P < 0.01 versus m/m; #P < 0.05 versus db/db veh, one-way ANOVA. Shenglan Wang et al. Diabetes 2018;67:98-109 ©2018 by American Diabetes Association