MϕRIP140KD mice exhibit improved metabolic phenotypes.

Slides:

Advertisements

Similar presentations

Peter L. Lee, Yuefeng Tang, Huawei Li, David A. Guertin

Advertisements

Figure Legend: From: High-Fat Diet–Induced Retinal Dysfunction

Volume 4, Issue 12, Pages (December 2015)

Valsartan Protects Pancreatic Islets and Adipose Tissue From the Inflammatory and Metabolic Consequences of a High-Fat Diet in Mice by Banumathi K. Cole,

Won Hee Choi, Jiyun Ahn, Chang Hwa Jung, Jung Sook Seo, Tae Youl Ha

Diet, Obesity, and Chronic Disease

Won Hee Choi, Jiyun Ahn, Chang Hwa Jung, Jung Sook Seo, Tae Youl Ha

Volume 37, Issue 3, Pages (September 2012)

White adipose tissue (HFD)

Volume 8, Issue 4, Pages (October 2008)

Metabolic profile of Tfe3 KO mice fed a HFD

Partial knockdown of MPST markedly ameliorates hepatic steatosis in vivo. Partial knockdown of MPST markedly ameliorates hepatic steatosis in vivo. (A–C)

Volume 21, Issue 4, Pages (October 2017)

Volume 22, Issue 1, Pages (July 2015)

Antidiabetic Effects of IGFBP2, a Leptin-Regulated Gene

Volume 17, Issue 5, Pages (May 2013)

Impaired glucose tolerance in adult S1/3 KO mice on a normal chow

Volume 3, Issue 3, Pages (March 2006)

Type 1 immunity drives metabolic disease but protects against NAFLD

Volume 18, Issue 10, Pages (March 2017)

Expression of NCoR1∆ID in PAX8−/− mice does not reverse repression of T3-positive target genes. qPCR on the indicated pituitary (A) and neuronal (B) genes.

Volume 37, Issue 3, Pages (September 2012)

Protection against High-Fat-Diet-Induced Obesity in MDM2C305F Mice Due to Reduced p53 Activity and Enhanced Energy Expenditure Shijie Liu, Tae-Hyung.

Antidiabetic Effects of IGFBP2, a Leptin-Regulated Gene

Improvement of insulin sensitivity by treatment of the annexin A1 receptor agonist in HFD mice. Improvement of insulin sensitivity by treatment of the.

Treatment with AAV8‐hAAT‐FGF21 improves insulin sensitivity and glucose tolerance Treatment with AAV8‐hAAT‐FGF21 improves insulin sensitivity and glucose.

Volume 20, Issue 1, Pages (July 2014)

Volume 10, Issue 5, Pages (November 2009)

Volume 23, Issue 4, Pages (April 2016)

Volume 25, Issue 4, Pages e4 (April 2017)

The preventive role of TR in HFD‐treated mice

Volume 19, Issue 3, Pages (March 2014)

(A) T2DM: serum glucose levels during glucose tolerance test (n=6 per group). (A) T2DM: serum glucose levels during glucose tolerance test (n=6 per group).

Therapeutic role of TR in HFD‐established diabetic mice

Transfer of NRP1-expressing bone marrow improves the metabolic phenotype of LysM-Cre-Nrp1fl/fl mice. Transfer of NRP1-expressing bone marrow improves the.

Volume 26, Issue 4, Pages e4 (January 2019)

Hyperinsulinemic-euglycemic clamps revealed that obese TPL2KO mice have an improved insulin sensitivity compared with obese WT mice. Hyperinsulinemic-euglycemic.

Intestinal CAV1 deletion alters circulating FFAs but not TGs

NRP1-expressing macrophages accumulate in adipose tissue during DIO and regulate weight gain and glucose tolerance. NRP1-expressing macrophages accumulate.

A working hypothesis for insulin action in the brain.

GLUT4 LXRE is required for downregulation of adipose GLUT4 mRNA during fasting and diet-induced obesity. GLUT4 LXRE is required for downregulation of adipose.

TXNIP and caspase-1 protein levels are increased in the adipose tissue of ob/ob mice. TXNIP and caspase-1 protein levels are increased in the adipose tissue.

ΑGLP-1R−/− mice show glucose intolerance and disturbed glucagon secretion in response to i.p. glucose administration. αGLP-1R−/− mice show glucose intolerance.

BAFF-deficient (BAFFnull) and anti-BAFF antibody (Ab)–treated obese mice exhibit superior glucose metabolic control compared with WT and Bnull mice. BAFF-deficient.

Effects of pterosin A on serum levels of lipid, blood urea nitrogen (BUN), creatinine, aspartate aminotransferase (AST), and alanine aminotransferase (ALT)

Adipose tissue dysfunction induces increased liver HIF-1α expression

ATL-801 treatment increases insulin sensitivity in KKAY mice.

Fig. 4 Deletion of hepatocyte HIF-2α does not affect obesity-induced glucose, glucagon, and insulin intolerance. Deletion of hepatocyte HIF-2α does not.

Rapid improvement of glucose tolerance induced by PP

SENP2 overexpression increases FAO by upregulating expression of FAO-associated enzymes in muscle. SENP2 overexpression increases FAO by upregulating expression.

MϕRIP140KD mice show browning in vWAT.

HFD feeding induced insulin resistance in TRIB3 MOE mice.

Hepatic fuel metabolism in male 5αR1-KO and WT mice

Mice fed GP-SPI diet show improved fasting glucose and oral glucose tolerance. Mice fed GP-SPI diet show improved fasting glucose and oral glucose tolerance.

Hepatic PPARγ deficiency impairs the SCFA-induced reduction in hepatic steatosis. Hepatic PPARγ deficiency impairs the SCFA-induced reduction in hepatic.

Insulin resistance and hepatic steatosis in ASKO mice.

Treatment of high-fat diet–fed mice with TTR-ASOs decreases circulating TTR and RBP4 levels, and improves insulin sensitivity. Treatment of high-fat diet–fed.

Effects of Rosi treatment on ASKO mice.

Effects of chow-diet feeding on control and TRIB3 MOE mice.

Effects of berberine on in vivo metabolism in two animal models of insulin resistance. Effects of berberine on in vivo metabolism in two animal models.

AP2-Cre–mediated IKKβ deletion results in similar defects in adipose remodeling and accentuated inflammatory responses after HF feeding. aP2-Cre–mediated.

GTTs and ITTs. A: GTTs of WT (◇), LepTg (♦), Akita (open circles), and LepTg:Akita (closed circles) mice at 8 and 16 weeks of age. GTTs and ITTs. A: GTTs.

High-fat diet–induced glucose intolerance is prevented in ghrelin knockout (Ghr-KO) mice. High-fat diet–induced glucose intolerance is prevented in ghrelin.

Shih-Yen Weng, Detlef Schuppan Journal of Hepatology

Metabolic parameters in the three groups of patients during l-arginine infusion. Metabolic parameters in the three groups of patients during l-arginine.

Deficiency of adipocyte IKKβ does not affect diet-induced weigh gain but results in an exaggerated diabetic phenotype when challenged with an HFD. A: IKKβ.

Volume 27, Issue 10, Pages e3 (June 2019)

Fig. 3 Loss of SBP2 in obesity exacerbated insulin resistance and adipogenesis. Loss of SBP2 in obesity exacerbated insulin resistance and adipogenesis.

Fig. 1. GDF15 is up-regulated with obesity, and AAV-GDF15 improves metabolic parameters in DIO mice. GDF15 is up-regulated with obesity, and AAV-GDF15.

Fig. 3. Effects of SFN in mice with diet-induced diabetes.

Presentation transcript:

MϕRIP140KD mice exhibit improved metabolic phenotypes. MϕRIP140KD mice exhibit improved metabolic phenotypes. A: The average body weight of WT and MϕRIP140KD (KD) mice fed an ND or HFD for 15 weeks. B: ITT and GTT determined after 15 weeks of ND or HFD feeding. C: Serum insulin, glucose, adiponectin, cholesterol, free fatty acid, and triglyceride levels in ND- or HFD-fed WT and KD mice. D: qPCR results showing mRNA levels of pro- and anti-inflammatory cytokines in the vWAT of ND- or HFD-fed WT and KD mice. E: Insulin signaling components in ND- or HFD-fed WT and KD adipose tissues. For A and B, two-way ANOVA test was performed. For C and D, Student test was used. All experiments were performed three times and presented as mean ± SD; n = 5 to 6 mice/group. *P < 0.05; **P < 0.01; ***P < 0.001. Pu-Ste Liu et al. Diabetes 2014;63:4021-4031 ©2014 by American Diabetes Association