Evidence for gene-environment interactions in a linkage study of asthma and smoking exposure Susan Colilla, PhDa*, Dan Nicolae, PhDb, Anna Pluzhnikov,

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Evidence for gene-environment interactions in a linkage study of asthma and smoking exposure Susan Colilla, PhDa*, Dan Nicolae, PhDb, Anna Pluzhnikov, PhDa, Malcolm N. Blumenthal, MDc, Terri H. Beaty, PhDd, Eugene R. Bleecker, MDe, Ethan M. Lange, PhDf, Stephen S. Rich, PhDf, Deborah A. Meyers, PhDe, Carole Ober, PhDa, Nancy J. Cox, PhDa Journal of Allergy and Clinical Immunology Volume 111, Issue 4, Pages 840-846 (April 2003) DOI: 10.1067/mai.2003.170 Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 1 Schematic diagram of how affected individuals in a family were stratified into exposed and unexposed groups. Journal of Allergy and Clinical Immunology 2003 111, 840-846DOI: (10.1067/mai.2003.170) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 2 Results from genome-wide linkage analysis of asthma in CSGA white families on the basis of ETS exposure. The thick black line represents the lod scores from all asthmatic patients, the pink line is for exposed asthmatic patients, and the green line represents unexposed asthmatic patients. Journal of Allergy and Clinical Immunology 2003 111, 840-846DOI: (10.1067/mai.2003.170) Copyright © 2003 Mosby, Inc. Terms and Conditions