Schematic diagram of the interactions between retromer and its associated proteins. Schematic diagram of the interactions between retromer and its associated.

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Schematic diagram of the interactions between retromer and its associated proteins. Schematic diagram of the interactions between retromer and its associated proteins. Here, the many retromer-interacting proteins that have been identified from studies in higher eukaryotes (e.g. mammalian cells) are depicted. Proteins have been grouped according to function, e.g. Snx3, Rab7a and TBC1D5 regulate the membrane association of the cargo-selective retromer complex. Arrows indicate the relationship between the respective proteins, e.g. Vps35 interacts with Fam21 to mediate recruitment of Fam21 and the WASH complex. In some cases, arrows are double-ended as the respective proteins are mutually dependent. Arrows with a dashed outline indicate an interaction that has not yet been experimentally proven, but is likely based on indirect evidence, e.g. native immunoprecipitations. Matthew N. J. Seaman J Cell Sci 2012;125:4693-4702 © 2012. Published by The Company of Biologists Ltd