Schematic diagram of the JCV genome.

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Schematic diagram of the JCV genome. Schematic diagram of the JCV genome. The circular Mad-1 genome is 5,130 bp and codes for 9 proteins: large T antigen (T), small t antigen (t), T′135, T′136, T′165, VP1, VP2, VP3, and agnoprotein. At the top is the NCCR, composed of the origin of replication (ORI) and two 98-bp repeats. Map units are denoted in the center circle. The early open reading frame (ORF) proceeds from the NCCR in the counterclockwise orientation and the late ORF in the clockwise direction. Proteins in the same reading frame are depicted in the same color. Start and stop sites are indicated. All transcripts are polyadenylated [(A)n]. Michael W. Ferenczy et al. Clin. Microbiol. Rev. 2012; doi:10.1128/CMR.05031-11