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Volume 85, Issue 6, Pages 1444-1453 (June 2014) Genetic and in vivo determinants of glucocorticoid sensitivity in relation to clinical outcome of childhood nephrotic syndrome Nynke Teeninga, Joana E. Kist-van Holthe, Erica L.T. van den Akker, Marie C. Kersten, Eric Boersma, Hans G. Krabbe, Nine V.A.M. Knoers, Albert J. van der Heijden, Jan W. Koper, Jeroen Nauta Kidney International Volume 85, Issue 6, Pages 1444-1453 (June 2014) DOI: 10.1038/ki.2013.531 Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 1 Glucocorticoid receptor gene haplotypes and their allelic frequencies in 108 children with nephrotic syndrome. DBD, DNA-binding domain; LBD, ligand-binding domain; TAD, transactivating domain. The symbols represent the presence of the minor allele of the SNP indicated. Kidney International 2014 85, 1444-1453DOI: (10.1038/ki.2013.531) Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 2 Glucocorticoid receptor gene haplotypes in relation to clinical outcome. Kaplan–Meier estimates of the first relapse, frequently relapsing nephrotic syndrome and steroid dependent nephrotic syndrome for carriers and noncarriers of the GR-9β haplotype (a, b, c) and the BclI haplotype (d, e, f). FRNS, frequently relapsing nephrotic syndrome; SDNS, steroid dependent nephrotic syndrome. Kidney International 2014 85, 1444-1453DOI: (10.1038/ki.2013.531) Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 3 Very low dose dexamethasone suppression test in 90 children with nephrotic syndrome. (a) Serum cortisol levels before and after dexamethasone; (b) correlation of pre- versus post-dexamethasone levels of serum cortisol; (c) post dexamethasone cortisol according to clinical outcome. Dex, dexamethasone; SD, steroid dependence; w/o, without. Kidney International 2014 85, 1444-1453DOI: (10.1038/ki.2013.531) Copyright © 2014 International Society of Nephrology Terms and Conditions