Achieving Fidelity in Homologous Recombination Despite Extreme Complexity: Informed Decisions by Molecular Profiling Robert P. Rambo, Gareth J. Williams,

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Presentation transcript:

Achieving Fidelity in Homologous Recombination Despite Extreme Complexity: Informed Decisions by Molecular Profiling Robert P. Rambo, Gareth J. Williams, John A. Tainer Molecular Cell Volume 40, Issue 3, Pages 347-348 (November 2010) DOI: 10.1016/j.molcel.2010.10.032 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 HR-Directed Search for the Homologous Sequence, Conformational Proofreading, Cost Optimization, and Signal Detection Theory (A) Structure of RecA (light blue) bound ssDNA complex. Alternating trinucleotide repeats (green or purple) illustrate B-DNA like geometry. (B) Arrows demarcate regions of extended deformation along the DNA backbone between trinucleotide units. (C) Base pairing between homologous DNA strands with deformed backbone geometry. (D) Binary game decision tree. Possible misinterpretation of coin toss can lead to false signal detection. Molecular Cell 2010 40, 347-348DOI: (10.1016/j.molcel.2010.10.032) Copyright © 2010 Elsevier Inc. Terms and Conditions