Food novelty is not sufficient to stimulate PSA production in the hypothalamus. Food novelty is not sufficient to stimulate PSA production in the hypothalamus.

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Food novelty is not sufficient to stimulate PSA production in the hypothalamus. Food novelty is not sufficient to stimulate PSA production in the hypothalamus. A, Photograph of STD, HFD, and CTRL diets. B, Fatty acid composition of diets, as determined by gas chromatography. C, Energy intake after STD, CTRL, or HFD feeding for 1 d. HFD was introduced once (HFD) or twice (HFD-2x), with 1 week maintenance on STD between the two exposures. D, Representative immunoblot of PSA levels detected in protein extracts from arcuate biopsies collected after STD, CTRL, or HFD feeding. E, PSA levels in arcuate biopsies from STD, CTRL, or HFD fed mice, measured by Western blot. HFD-2x = reexposure to HFD. Data are means ± SEM of n = 9 (STD), 5 (HFD), 7 (CTRL), and 7 (HFD-2x). In C and E, groups were compared using the Mann–Whitney test. Significant difference at *p < 0.05 or ***p < 0.001, respectively. Alexandre Benani et al. J. Neurosci. 2012;32:11970-11979 ©2012 by Society for Neuroscience