Effects of chow-diet feeding on control and TRIB3 MOE mice.

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Effects of chow-diet feeding on control and TRIB3 MOE mice. Effects of chow-diet feeding on control and TRIB3 MOE mice. A: TRIB3 MOE mice exhibited higher BW gain. B: Quantitative MRI test shows increases of fat mass and lean mass contributed to gain of BW in TRIB3 MOE mice. C and D: No significant differences were observed on glucose tolerance test (GTT) and blood glucose levels in mice fed the chow diet. E: Physical activity for 24 h was similar between control and TRIB3 MOE mice. F: RER was similar between control and TRIB3 MOE mice. G and H: TRIB3 MOE mice exhibited decreased 24-h energy expenditure normalized by total BW or total body lean mass. I: Endogenous mouse TRIB3 expressions were suppressed in skeletal muscle under fasting and feeding conditions, In addition, physiological regulation of endogenous mouse TRIB3 expression by nutrient availability was blunted in skeletal muscle of TRIB3 MOE mice. J: Expression and nutrient regulation of endogenous mouse TRIB3 in liver were not affected in TRIB3 MOE mice. Data are the means ± SEM (n = 7–12). *P < 0.05, **P < 0.01, and ***P < 0.001 vs. control group by Student t test or two-way ANOVA; #P < 0.05, ###P < 0.001 vs. Fast control group. Wei Zhang et al. Diabetes 2016;65:2380-2391 ©2016 by American Diabetes Association