Detection of neoantigen-specific T cell recognition in cancer.

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Detection of neoantigen-specific T cell recognition in cancer. Detection of neoantigen-specific T cell recognition in cancer. (A) Antigen-specific T cells in melanoma TILs identified by the combinatorial color encoding strategy using empty-loadable DS-A2 multimers. pMHC multimers for 54 A2-restricted peptides (43 neoantigens, 5 melanoma-associated cancer antigens, and 6 virus-derived antigens) were generated, each in a two-color combination. Frequency of pMHC multimer–positive cells out of total CD8+ T cells is shown as colored dots across three categories. Multimer-negative cells are plotted in gray for each pMHC combination (zero values are converted to 0.0001 to plot on log scale). (B) Dot plots of the antigen-specific T cell populations from (A), each is shown with indicated fluorochromes and peptide sequences. The mutated amino acid position of the neoantigens is highlighted in red. Sunil Kumar Saini et al. Sci. Immunol. 2019;4:eaau9039 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works