Volume 60, Issue 5, Pages (November 2001)

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Volume 60, Issue 5, Pages 1737-1744 (November 2001) Parathyroid hyperplasia in uremic rats precedes down-regulation of the calcium receptor Cynthia S. Ritter, Jane L. Finch, Eduardo A. Slatopolsky, Alex J. Brown, Ph.D. Kidney International Volume 60, Issue 5, Pages 1737-1744 (November 2001) DOI: 10.1046/j.1523-1755.2001.00027.x Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 1 Representative images of the changes in proliferative cell nuclear antigen (PCNA) and calcium-sensing receptor (CaR) expression in uremic rats maintained on a high phosphate diet that promotes parathyroid hyperplasia. PCNA and CaR content were examined by immunohistochemical staining of sections of formalin-fixed, paraffin-embedded parathyroid glands (magnification, PCNA ×400, CaR ×100). Kidney International 2001 60, 1737-1744DOI: (10.1046/j.1523-1755.2001.00027.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 2 Time course of changes in PCNA (▪) and CaR (•) expression for protocol 1. Rats were made uremic and placed immediately on a high phosphate (HP) diet that promotes parathyroid hyperplasia. Intact control rats (day 0) were fed a regular chow diet. CaR protein content was assessed by immunohistochemical staining and quantified by computer-assisted analysis and reported as optical density, % of control values. Cell proliferation was determined as the number of PCNA-positive cells per unit area (1000 pixels), and reported as % of control values. Data are expressed as mean ± SE, P ≤ 0.01. Kidney International 2001 60, 1737-1744DOI: (10.1046/j.1523-1755.2001.00027.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 3 Time course of changes in PCNA (▪) and CaR (•) expression for protocol 2. Uremic rats were maintained on a low phosphate (LP) diet for one week before being switched to a high phosphate (HP) diet that promotes parathyroid hyperplasia. Intact control rats were maintained on a regular chow diet. CaR protein content was assessed by immunohistochemical staining, quantified by computer-assisted analysis, and reported as optical density, % of control values. Cell proliferation was determined as the number of PCNA-positive cells per unit area (1000 pixels), and reported as % of control values. Data are expressed as mean ± SE, P ≤ 0.01. Kidney International 2001 60, 1737-1744DOI: (10.1046/j.1523-1755.2001.00027.x) Copyright © 2001 International Society of Nephrology Terms and Conditions