Volume 58, Issue 2, Pages (August 2000)

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Volume 58, Issue 2, Pages 881-888 (August 2000) Bradykinin and nitric oxide generation by dialysis membranes can be blunted by alkaline rinsing solutions Rosanna Coppo, Alessandro Amore, Paola Cirina, Bibiana Scelfo, Franca Giacchino, Luciano Comune, Mauro Atti, Jean Louis Renaux Kidney International Volume 58, Issue 2, Pages 881-888 (August 2000) DOI: 10.1046/j.1523-1755.2000.00238.x Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 1 Dose-dependent release of nitric oxide (NO) by endothelial cell (EC) cultures in response to increasing concentrations of bradykinin (BK). Nitric oxide synthase (NOS) activity in EC cultures was evaluated after 30 (▪), 60 (), and 360 () minutes of incubation with graded amounts of BK, ranging from 0 to 10,000 fmol/mL. Data are expressed as fold increases of values found in unconditioned cells. Columns report the mean ± SD of four experiments, each in triplicate. Kidney International 2000 58, 881-888DOI: (10.1046/j.1523-1755.2000.00238.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 2 Western blot of phosphorylated tyrosine kinases. ECs were incubated with 5000 fmol/mL BK for 45 minutes and 6 hours. Lane 1, unconditioned cells. Lane 2, BK (5000 fmol/mL) for 45 minutes. Lane 3, BK (5000 fmol/mL) for six hours. Two bands of 60 and 145 kD were found in lanes 2 and 3. Kidney International 2000 58, 881-888DOI: (10.1046/j.1523-1755.2000.00238.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 3 Effect of the culture medium pH on NOS activity in EC cultures. Time courses of NOS activity were performed in ECs cultured in pH 7.2 (○) or pH 7.6 (▪) media. Data are expressed as fold increases of values found in unconditioned cells. Each point reports the mean ± SD of four experiments, each in triplicate. Kidney International 2000 58, 881-888DOI: (10.1046/j.1523-1755.2000.00238.x) Copyright © 2000 International Society of Nephrology Terms and Conditions