Drug transport mechanism of AcrB.

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Drug transport mechanism of AcrB. Drug transport mechanism of AcrB. Shown is the asymmetric crystal structure of AcrB (Protein Data Bank accession number 2DRD), viewed from outside the cell, with the top portion cut off for clarity. Conformational cycling of 3 AcrB protomers, in access (blue), binding (red), and extrusion (green), is seen by cocrystallization of AcrB with its substrate minocycline, shown in a yellow stick model. Xian-Zhi Li et al. Clin. Microbiol. Rev. 2015; doi:10.1128/CMR.00117-14