Local expression of ϵ germline gene transcripts and RNA for the ϵ heavy chain of IgE in the bronchial mucosa in atopic and nonatopic asthma Sun Ying,

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Presentation transcript:

Local expression of ϵ germline gene transcripts and RNA for the ϵ heavy chain of IgE in the bronchial mucosa in atopic and nonatopic asthma Sun Ying, PhDa, Marc Humbert, MDa, Qiu Meng, MDa, Rudi Pfister, MDd, Gunter Menz, MDd, Hannah J. Gould, PhDc, A.Barry Kay, MDa, Stephen R. Durham, MDb Journal of Allergy and Clinical Immunology Volume 107, Issue 4, Pages 686-692 (April 2001) DOI: 10.1067/mai.2001.114339 Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 1 Immunohistochemistry/in situ hybridization studies of the bronchial mucosa. A , B lymphocytes immunostained with anti-CD20 antibody. Positive cells stain red (arrows) . B and C , Individual Cϵ and Iϵ RNA+ cells detected by using digoxin-labeled antisense RNA probes. Positive cells stain dark blue (arrows) . D , Cells stained sequentially with anti-CD20 followed by hybridization with an antisense RNA probe against Cϵ. Double-positive cells stain purple (arrows) . Journal of Allergy and Clinical Immunology 2001 107, 686-692DOI: (10.1067/mai.2001.114339) Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 2 Iϵ and Cϵ expression in the bronchial mucosa in asthmatic and control subjects. Results are expressed as the number of RNA+ cells per square millimeter of bronchial mucosa. Circles refer to atopic (filled circles) and nonatopic (open circles) asthmatic subjects. Triangles refer to atopic (filled triangles) and nonatopic (open triangles) nonasthmatic control subjects. Bars represent median values. Levels of statistical significance compared with the nonatopic control group are shown (Mann-Whitney U test). Journal of Allergy and Clinical Immunology 2001 107, 686-692DOI: (10.1067/mai.2001.114339) Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 3 Relationship between IL-4 and ϵ gene expression in the bronchial mucosa in asthma. Atopic asthmatic subjects are represented by filled circles . Nonatopic asthmatic subjects are represented by open circles . Correlation was done with the Spearman rank method. Journal of Allergy and Clinical Immunology 2001 107, 686-692DOI: (10.1067/mai.2001.114339) Copyright © 2001 Mosby, Inc. Terms and Conditions