When cannabis is smoked the active principle of this drug, THC, reaches the brain

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Presentation transcript:

The CB1 receptor is one of the most abundant neurotransmitter receptors in the brain

When cannabis is smoked the active principle of this drug, THC, reaches the brain

THC then binds to the CB1 receptor

THC then binds to the CB1 receptor

Cannabis Intoxication THC over-activates the CB1 inducing cannabis intoxication Cannabis Intoxication

Cannabis Intoxication Higher doses of THC, above those found in cannabis smokers, increase pregnenolone levels in the brain THC over-activates the CB1 inducing cannabis intoxication Cannabis Intoxication

Cannabis Intoxication Pregnenolone then binds to a specific site on the CB1 Cannabis Intoxication

Pregnenolone decreases the effects of THC on the CB1

Cannabis intoxication is then reduced Cannabis Effects

Reduced Cannabis Effects Pregnenolone is a natural defense that can protect the brain from cannabis Reduced Cannabis Effects