OTU and family-level changes in murine gut as a result of acarbose feeding on a high-starch diet. OTU and family-level changes in murine gut as a result.

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OTU and family-level changes in murine gut as a result of acarbose feeding on a high-starch diet. OTU and family-level changes in murine gut as a result of acarbose feeding on a high-starch diet. (A, B) Relative abundances over time of the two OTUs that increased the most in response to acarbose treatment. OTUs that significantly changed in response to acarbose treatment were identified by a Friedman test on each OTU, with Benjamini-Hochberg correction for multiple comparisons. OTU2 and OTU3 had the largest increases in relative abundance among OTUs that significantly changed. (C, D) Relative abundances over time of two OTUs that decreased the most in response to acarbose treatment. OTUs that significantly changed in response to acarbose treatment were identified by repeated measures analysis of variance (ANOVA) on each OTU, with correction for multiple comparisons. OTU1, OTU13, and OTU8 had the largest decreases in relative abundance among OTUs that significantly changed. All OTUs shown had adjusted P values of <10−5. (E) Relative abundances of the 8 most abundant bacterial families, which accounted for more than 93% of sequences. *, P < 0.05 by Wilcoxon rank sum test, high versus control. Nielson T. Baxter et al. mSphere 2019; doi:10.1128/mSphere.00528-18