LATS2 augments oxidative phosphorylation.

Slides:

Advertisements

Similar presentations

Supplementary Fig. 1. Transcriptome analysis of MENX-associated pituitary adenomas and and comparison with human studies. Control samples from wild-type.

Advertisements

Volume 11, Issue 10, Pages (June 2015)

Volume 11, Issue 4, Pages (April 2007)

* Supplementary Figure 1 A N.S B C D E basal Glycolytic reserve

A. B. Online resource 7 Soria G. et al. Submitted to Neoplasia

Volume 21, Issue 11, Pages (December 2017)

Rapamycin Suppresses Tumor Growth and Alters the Metabolic Phenotype in T-Cell Lymphoma Wasakorn Kittipongdaja, Xuesong Wu, Justine Garner, Xiping Liu,

Volume 21, Issue 11, Pages (December 2017)

(A) ZR75-1 cells were treated with 1 μM 5-aza-2′-deoxycytidine (5-Aza) for 4 d. (A) ZR75-1 cells were treated with 1 μM 5-aza-2′-deoxycytidine (5-Aza)

PPARγ signaling correlates with LATS2 in human and mouse tumors and promotes cell death in a LATS2-dependent manner. PPARγ signaling correlates with LATS2.

Validation cell‐type‐enriched culturing methods, metabolome dynamics, and mitochondria abundance and bioenergetics in differentiating organoids Validation.

Volume 23, Issue 11, Pages (June 2018)

Expression and regulation of MD-2s.

LATS2 is a tumor suppressor in a mouse lumB breast cancer model.

(A) Schematic representation of the conditional Lats1 locus.

Volume 7, Issue 3, Pages (May 2014)

Immunometabolic Pathways in BCG-Induced Trained Immunity

Volume 10, Issue 8, Pages (March 2015)

Microarray analysis of phospho-Twist1–responsive genes.

Deletion of Lats1 is phenotypically distinct from Lats2 deletion in PyMT tumors. Deletion of Lats1 is phenotypically distinct from Lats2 deletion in PyMT.

Volume 10, Issue 3, Pages (March 2018)

GAK phosphorylates Atp1a3 at novel site T705 in HEK 293Ts.

Volume 16, Issue 3, Pages (July 2016)

LATS2 promotes death of lumB cells.

Volume 22, Issue 4, Pages (October 2015)

Volume 16, Issue 7, Pages (August 2016)

Volume 18, Issue 2, Pages (February 2016)

Volume 22, Issue 10, Pages (March 2018)

Volume 23, Issue 3, Pages (March 2013)

Volume 9, Issue 3, Pages (September 2017)

(A) Genotyping of the Lats2 and Cre alleles in the PyMT-derived cell lines (see primers location in Fig S2A). (A) Genotyping of the Lats2 and Cre alleles.

Modeling Developmental and Tumorigenic Aspects of Trilateral Retinoblastoma via Human Embryonic Stem Cells Yishai Avior, Elyad Lezmi, Dorit Yanuka, Nissim.

Volume 15, Issue 6, Pages (May 2016)

Down-regulation of LATS1 promotes the formation of tumors enriched in basal-like features. Down-regulation of LATS1 promotes the formation of tumors enriched.

Volume 20, Issue 2, Pages (February 2012)

Bexarotene is neuroprotective in mouse and human HD neurons in vitro

Existence of a nuclear NFATc1–STAT3 complex in pancreatic cancer.

Protein tyrosine kinase 7 is involved in Wnt/β‐catenin canonical signalling. Protein tyrosine kinase 7 is involved in Wnt/β‐catenin canonical signalling.

HDAC11 regulates CCL2 expression by recruiting PU.1.

MAPK14 regulates ROS generation in GS cells.

TRAF4 is required for EGFR activation in response to EGF stimulation.

Expression profiles of 5,493 transcripts grouped by k-means clustering

LATS2-associated gene expression pattern is down-regulated specifically in lumB breast tumors. LATS2-associated gene expression pattern is down-regulated.

Metascape Tripathi et al 2015pathways enrichment analysis (Tripathi et al 2015, of differentially expressed genes (counts > 5, FC.

(A) Schematic representation of the conditional Lats2 locus.

Cellular localization of r-proteins during repression of a 40S or a 60S r-protein gene. Cellular localization of r-proteins during repression of a 40S.

(A) Distribution of LATS2 mRNA expression levels in different breast cancer subtypes (PAM50, METABTIC dataset); ***P-value < 0.001, t test comparing lumB.

Figure 3 Loss of MICU1 leads to a deficit in mitochondrial calcium handling without impairing respiration Loss of MICU1 leads to a deficit in mitochondrial.

Appearance of prominin-1-containing membrane particles in the culture medium upon differentiation of Caco-2 cells. Appearance of prominin-1-containing.

Comparison ofMyc-induced zebrafish liver tumors with different stages of human HCC and seven mouse HCC models. Comparison ofMyc-induced zebrafish liver.

Crim1 colocalizes with integrin and activates the integrin-FAK-ERK signaling pathway. Crim1 colocalizes with integrin and activates the integrin-FAK-ERK.

JAK3A572V mutation causes constitutive JAK3 activity and IL-2–independent proliferation of NKTCL cells. JAK3A572V mutation causes constitutive JAK3 activity.

Caveolin-1 downregulated survivin expression in cells with enhanced or constitutive activity via the Wnt pathway. Caveolin-1 downregulated survivin expression.

(A) Relative expression levels of the top most down-regulated genes in LATS2L breast tumors (TCGA-BRCA dataset, see Fig 1) in the panel of breast cancer.

CPPED1 (A) and PPARγ2 (B) mRNA expressions in cultured SGBS cells during adipocyte differentiation. CPPED1 (A) and PPARγ2 (B) mRNA expressions in cultured.

Ectopic expression of caveolin-1 in ZR75 human breast cancer cells downregulated survivin and decreased cell proliferation. Ectopic expression of caveolin-1.

BCL-3 regulates expression of stemness-associated Wnt targets.

Ctip2 directly regulates Notch1 expression in differentiated cells.

Enrichment of KEGG pathways in microbial genes in different samples.

KEGG categories of host DEGs (up- and downregulated genes) enriched at selected points after φAbp1 infection. KEGG categories of host DEGs (up- and downregulated.

Aggregation and toxicity of α-synuclein in HEK293T cells.

Induction of CDCP1 is regulated by Ras in NSCLC cells.

FcRγ signaling regulates BTK activation and mediates PDAC growth.

Volume 11, Issue 10, Pages (June 2015)

Volume 18, Issue 11, Pages (March 2017)

CCR5 enhances both HDR and SSA DNA repair.

Transcriptional activity and growth of mutant ER in a breast cancer cell line. Transcriptional activity and growth of mutant ER in a breast cancer cell.

Expression of PKM2 Y105F mutant in H1299 cells leads to decreased proliferation under hypoxic conditions, increased oxidative phosphorylation and reduced.

Differences in tumour cell metabolism and cytokine/chemokine expression among the three HCC subtypes. Differences in tumour cell metabolism and cytokine/chemokine.

Cxxc1-deficient TH17 cells exhibit a Treg cell–like expression profile

Presentation transcript:

LATS2 augments oxidative phosphorylation. LATS2 augments oxidative phosphorylation. (A) KEGG pathways enrichment analysis for genes differentially regulated in Lats2-CKO PyMT compared with WT-PyMT tumors (adjP-value < 0.05, n = 114). (B) ZR75-1 cells stably transfected with an MYC-LATS2 plasmid (LATS2) or with control vector were cultured with or without glucose for 3 d. Cell death was measured by PI exclusion followed by FACS analysis. Values from each experiment were normalized to % PI+ of control cells grown in glucose-containing medium; mean ± SEM of three independent experiments. (C) Extracellular acidification rate (ECAR, indicative of glycolysis) and oxygen consumption rate (OCR, indicative of respiration) of ZR75-1 cells stably expressing MYC-LATS2, relative to vector control cells, determined by Seahorse; mean ± SEM of five independent experiments. Representative tracks of Seahorse measurements are shown on the right. (D) Respiration measured by OCR in WT-PyMT and Lats2-CKO PyMT tumor-derived cell lines; mean ± SEM in log 10 scale of three independent experiments; P-value < 0.05. Bottom: representative Seahorse track. Noa Furth et al. LSA 2018;1:e201800171 © 2018 Furth et al.