Emily M. DeBoer, MD, David R. Spielberg, MD, MHSc, Alan S. Brody, MD

Slides:

Advertisements

Similar presentations

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

Advertisements

D-dimer: A biomarker for antihistamine-resistant chronic urticaria

Peter Vadas, MD, PhD, Boris Perelman, PhD, Gary Liss, MD, MS

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD

What drives prescription patterns in pediatric asthma management?

What effect does asthma treatment have on airway remodeling

Information technology–based approaches to reducing repeat drug exposure in patients with known drug allergies Kathrin M. Cresswell, MSc, Aziz Sheikh,

Allergen immunotherapy: A practice parameter third update

Anne M. Fitzpatrick, PhD, MSCR, W. Gerald Teague, MD

Airway fibroblasts exhibit a synthetic phenotype in severe asthma

Obstructive sleep apnea syndrome and inflammation

Information technology–based approaches to reducing repeat drug exposure in patients with known drug allergies Kathrin M. Cresswell, MSc, Aziz Sheikh,

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Robert M. Naclerio, MD, Jayant Pinto, MD, Fuad Baroody, MD

Disparities in allergic disease: Hypersensitivity and social disorders

Treatment of chronic rhinosinusitis with intranasal amphotericin B: A randomized, placebo-controlled, double-blind pilot trial Jens U. Ponikau, MD, David.

David A. Khan, MD Journal of Allergy and Clinical Immunology

Dorothy M. Ryan, MD, Stephen J. Fowler, MD, Robert M. Niven, MD

Is 9 more than 2 also in allergic airway inflammation?

Desensitization to Chemotherapeutic Agents

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD

Using imaging as a biomarker for asthma

Asthma therapy and airway remodeling

An Infant with Atopic Dermatitis and Itching After Ingestion of Milk

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Practice Notes from the AAAAI

Mark S. Dykewicz, MD Journal of Allergy and Clinical Immunology

Peter M. Wolfgram, MD, David B. Allen, MD

Asthma treatment and asthma prevention: A tale of 2 parallel pathways

Aimee L. Speck, MD, Michael Hess, MSI, Alan P. Baptist, MD, MPH

Reply Journal of Allergy and Clinical Immunology

Environmental determinants of allergy and asthma in early life

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

Inhaled allergen bronchoprovocation tests

Phillip Lieberman, MD, David Golden, MD

The role of the mast cell in the pathophysiology of asthma

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Biosimilars and drug development in allergic and immunologic diseases

Peter Vadas, MD, PhD, Boris Perelman, PhD, Gary Liss, MD, MS

Sharon Seth, MD, David A. Khan, MD

What is an “eosinophilic phenotype” of asthma?

Michelle R. Zeidler, MD, MS, Jonathan G. Goldin, MD, PhD, Eric C

Cephalosporin Side Chain Cross-reactivity

Medication use in children with asthma in Finland from 1995 to 2006

What the asthma end points we know and love do and do not tell us

Granulomatous-lymphocytic Interstitial Lung Disease in a Patient with Common Variable Immunodeficiency Phil Lieberman, MD, John Routes, MD The Journal.

H. William Kelly, PharmD Journal of Allergy and Clinical Immunology

Autophagy: Nobel Prize 2016 and allergy and asthma research

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Advances in the approach to the patient with food allergy

A single intervention for cockroach control reduces cockroach exposure and asthma morbidity in children Felicia A. Rabito, PhD, MPH, John C. Carlson,

E. Rand Sutherland, MD, MPH Journal of Allergy and Clinical Immunology

Biology of nasal polyposis

Martin Brasholt, MD, Florent Baty, PhD, Hans Bisgaard, MD, DMSci

Sonja A. Grundmann, MD, Pia B. Hemfort, MD, Thomas A

Sustained response to mepolizumab in refractory Churg-Strauss syndrome

Glucocorticoid-induced osteoporosis: An update on effects and management Bjoern Buehring, MD, Ravi Viswanathan, MD, Neil Binkley, MD, William Busse, MD

Nitric oxide as a clinical guide for asthma management

Biju Thomas, MD, Robert Anthony Hirst, PhD, Mina H

Measles and immunomodulation

Macrolide antibiotics and asthma treatment

Statistical issues in clinical trials that involve the double-blind, placebo-controlled food challenge Vernon M. Chinchilli, PhD, Laura Fisher, MD, Timothy.

Asthma: The past, future, environment, and costs

Environmental factors and eosinophilic esophagitis

News & Notes Journal of Allergy and Clinical Immunology

Advances in pediatric asthma in 2007

Safety and efficacy of repeated monthly carboplatin desensitization

Natural history of cow’s milk allergy

Susan L. Janson, DNSc, Kelly Wong McGrath, BA, Jack K

Primary prevention of asthma and allergy

Presentation transcript:

Clinical potential for imaging in patients with asthma and other lung disorders Emily M. DeBoer, MD, David R. Spielberg, MD, MHSc, Alan S. Brody, MD Journal of Allergy and Clinical Immunology Volume 139, Issue 1, Pages 21-28 (January 2017) DOI: 10.1016/j.jaci.2016.11.004 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Quantitative CT in a patient with severe asthma shows airway narrowing (B) and increased low-attenuation areas, a marker of hyperinflation (D), when compared with a healthy subject (A and C).39 Journal of Allergy and Clinical Immunology 2017 139, 21-28DOI: (10.1016/j.jaci.2016.11.004) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 HP gas MRI images can reveal lung ventilation changes before and after medical or surgical interventions without concern for repeated radiation exposures. Shown here are images obtained from a patient at baseline and 3 months after undergoing bronchial thermoplasty. Reproduced with permission of the Radiological Society of North America, from Thomen et al.71 Journal of Allergy and Clinical Immunology 2017 139, 21-28DOI: (10.1016/j.jaci.2016.11.004) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 A, Chest EIT data are gathered by measuring the voltage across electrodes placed around the circumference of the chest after applying a defined current. B, Conductivity, a measure of impedance, is calculated for pixels in the cross-sectional plane of the electrodes, and an estimate of continuous ventilation and perfusion in an axial plane of a patient's chest is produced. Journal of Allergy and Clinical Immunology 2017 139, 21-28DOI: (10.1016/j.jaci.2016.11.004) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Optical coherence tomography combined with flexible bronchoscopy can visualize microscopic airway characteristics, including epithelium (EPI), basement membrane (BM), and smooth muscle (SM). Reproduced with permission of the European Respiratory Society from Kirby et al.96 Journal of Allergy and Clinical Immunology 2017 139, 21-28DOI: (10.1016/j.jaci.2016.11.004) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions