Vitamin K for reversal of excessive vitamin K antagonist anticoagulation: a systematic review and meta-analysis by Rasha Khatib, Maja Ludwikowska, Daniel M. Witt, Jack Ansell, Nathan P. Clark, Anne Holbrook, Wojtek Wiercioch, Holger Schünemann, and Robby Nieuwlaat BloodAdv Volume 3(5):789-796 March 12, 2019 © 2019 by The American Society of Hematology

All-cause mortality. −, low risk of bias; +, high risk of bias; All-cause mortality. −, low risk of bias; +, high risk of bias; ?, unkown risk of bias; df, degree of freedom; M-H, Mantel Haenszel; trt, treatment. All-cause mortality. −, low risk of bias; +, high risk of bias; ?, unkown risk of bias; df, degree of freedom; M-H, Mantel Haenszel; trt, treatment. Rasha Khatib et al. Blood Adv 2019;3:789-796 © 2019 by The American Society of Hematology

Major bleeding. Major bleeding. Rasha Khatib et al. Blood Adv 2019;3:789-796 © 2019 by The American Society of Hematology

Any thromboembolism event. Rasha Khatib et al. Blood Adv 2019;3:789-796 © 2019 by The American Society of Hematology

Proportion of patients who reached goal INR values. Rasha Khatib et al. Blood Adv 2019;3:789-796 © 2019 by The American Society of Hematology