IL-27 induces expression of multiple IR by CD8+ T cells.

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IL-27 induces expression of multiple IR by CD8+ T cells. IL-27 induces expression of multiple IR by CD8+ T cells. Naive, Ly6C–Sca-1– CD8+ and T cells were sort purified and cultured in the presence or absence of α-CD3/28, in the presence or absence of IL-27. After an 85-h culture, cells were analyzed for expression of PD-L1, PD-1, LAG-3, and CTLA-4. Representative FACS plots (left). Bar charts (right) show combined results from four independent experiments. Error bars indicate SEM. Statistical significance was determined by using Student t test. ns; p > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001. Jonathan H. DeLong et al. ImmunoHorizons 2019;3:13-25 Copyright © 2019 The Authors